Evaluation of a Portable Blood Lead Analyzer with Occupationally Exposed Populations

Details

• Personal Author:
  Ashley, Kevin E. ; Deddens JA ; Jones RL ; Kwan L ; Sanderson, Wayne T. ; Taylor L
• Description:
  This project evaluated a portable electroanalytical instrument that is used to rapidly analyze blood lead levels in individuals, using a fresh whole blood sample (venous). Samples were obtained from 208 lead-exposed employees who donated two 2 ml venous blood samples into "lead-free" evacuated tubes. One blood sample was analyzed onsite using the portable field instrument while the second sample was analyzed using graphite furnace atomic absorption spectrometry (GFAAS). According to GFAAS results, employee venous blood lead levels ranged from 1 microg/dl to 42 microg/dl. The mean difference between the results from the field instrument and GFAAS was less than 1 microg/dl. Analysis indicates that the results from the field instrument yielded a slight positive bias overall (P value = 0.0213), with less bias for blood lead levels above 10 microg/dl (P value = 0.0738). Within the blood range evaluated (1-42 microg/dl), the instrument performed adequately according to Clinical Laboratory Improvements Amendments (CLIA) proficiency requirements. The ability of the instrument to perform rapid analysis makes it potentially valuable to occupational health professionals for medical monitoring or on-site investigations. [Description provided by NIOSH]
• Subjects:
  Hematologic Tests Lead Occupational Exposure Occupational Health Safety
• Keywords:
  Anodic Stripping Voltammetry Author Keywords: Electroanalytical Instrument Blood-analysis Blood-sampling Blood Lead Analysis Blood Lead Monitoring Employee-exposure Instrument Evaluation Lead-compounds Occupational-exposure Occupational-health

  More +
• ISSN:
  0271-3586
• Publisher:
  Wiley-Liss, Inc.
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  354-362
• Volume:
  40
• Issue:
  4
• NIOSHTIC Number:
  nn:20021890
• Citation:
  Am J Ind Med 2001 Oct; 40(4):354-362
• Contact Point Address:
  Centers for Disease Control and Prevention/ National Institute for Occupational Safety and Health, Division of Surveillance, Hazard Evaluations and Field Studies, 4676 Columbia Parkway, Cincinnati, OH 45226, USA
• Email:
  LTaylor@cdc.gov
• CAS Registry Number:
  Lead (CAS RN 7439-92-1)
• Editor(s):
  Landrigan PJ
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Work Environment and Workforce: Mixed Exposures
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Industrial Medicine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:cce0890b8633345e95092a91e70e27a629e85950c41c1d25938591ba1f3bbc849397ce186d0d921510359dde1e9a98ef10806da0917ec8b2d8bc1e892d552bcc
• Download URL:
  https://stacks.cdc.gov/view/cdc/198976/cdc_198976_DS1.pdf
• File Type:
  [PDF - 165.70 KB ]