Reactive Oxygen Species and Molecular Mechanism of Silica-Induced Lung Injury

Details

• Personal Author:
  Castranova, Vincent ; Chen F ; Ding M ; Rojanasakul Y ; Shi X ; Vallyathan V ; Wang L
• Description:
  Silica particles are considered to be fibrogenic and carcinogenic agents, but the mechanisms of disease initiation and progression are not fully understood. This article summarizes the literature on the generation of reactive oxygen species (ROS) directly from interaction of silica with aqueous medium and from silica-stimulated cells. This article also discusses the role of ROS in silica-induced lung injury, with particular focus on the silica-induced NF-kappaB activation, including the molecular mechanisms of its regulation, its possible attenuation, and its relationship to silica-induced generation of cyclooxygenase II and TNF-alpha. [Description provided by NIOSH]
• Subjects:
  Carcinogens Lung Occupational Health Respiratory System Safety Silicosis
• Keywords:
  Author Keywords: Silicosis Cyclooxygenase II Diseases Fibrogenicity Free Radicals Injuries NF-kappaB Reacive Oxygen Species TNF-alpha
• ISSN:
  0731-8898
• Publisher:
  Begell House Incorporated
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  85-93
• Volume:
  20
• NIOSHTIC Number:
  nn:20021871
• Citation:
  J Environ Pathol Toxicol Oncol 2001 Jan; 20(Suppl 1):85-93
• Email:
  xas0@cdc.gov
• Editor(s):
  Moran EM
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Other Occupational Concerns ; Pulmonary System Disorders
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Environmental Pathology, Toxicology, and Oncology
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:febec62152582ec6b2e3fb4335828fdd73a1b58bd77bde63554965835456a5b3eef95f71ec306fbc601a9505caf0a467f171d4604309f9351c3db230f25e8f65
• Download URL:
  https://stacks.cdc.gov/view/cdc/198959/cdc_198959_DS1.pdf
• File Type:
  [PDF - 336.79 KB ]