Intratracheal Amiodarone Administration to F344 Rats Causes Acute Damage to Airway and Parenchymal Cells: The Possible Role of Free Radical Generation

Details

• Personal Author:
  Antonini JM ; Bowman LL ; Castranova, Vincent ; Hubbs, Ann F. ; Leonard, Stephen S. ; Reasor MJ ; Roberts, Jennifer R. ; Shi X ; Taylor MD ; Van Dyke K
• Description:
  Intratracheal (i.t) instillation of the antiarrhythmic drug amiodarone (AD) leads to lung damage, inflammation, and fibrosis in F344 rats. To assess the direct effect of AD in this damage, male F344 rats were instilled with 6.25 mg/kg AD (3.125 mg/ml solution in sterile water) or the sterile water vehicle and subjected to bronchoalveolar lavage (BAL) at 15 min, 1 hr, and 3hr following i.t. treatment. The blood protein albumin was markedly elevated in the first BAL fraction of AD-treated animals at these time points, indicating an early damage to the alveolar-capillary barrier. [Description provided by NIOSH]
• Subjects:
  Animals Fibrosis Laboratories Lung Occupational Health Respiratory System Safety
• Keywords:
  Animal-studies Laboratory-animals Laboratory-testing Proteins
• ISSN:
  1096-6080
• Publisher:
  Oxford University Press
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  60
• Issue:
  1
• NIOSHTIC Number:
  nn:20021465
• Citation:
  Toxicologist 2001 Mar; 60(1):424
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 40th Annual Meeting, March 25-29, 2001, San Francisco, California
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:08ff89d6f008280e7d707b96f33a70def5db6e7daf03656bb3f0aa001dc197abd1c3ffdc35b9e759019ff1c6867408fa07f241e413ad5217c54f4e9f3b01b761
• Download URL:
  https://stacks.cdc.gov/view/cdc/198769/cdc_198769_DS1.pdf
• File Type:
  [PDF - 126.70 KB ]