Enhanced Oxidative Stress in the Skin of Vitamin E-Deficient Mice Exposed to Metal Working Fluid

Details

• Personal Author:
  Castranova, Vincent ; Kisin E ; Kommineni C ; Murray A ; Shvedova AA ; Smith C
• Description:
  Metal working fluids (MWFs) are widely used in industry for metal cutting, drillings, shaping, lubricating, and milling. Many occupational health concerns have arisen for workers exposed to MWFs. It has been reported earlier that occupational exposure to MWFs causes allergic and irritant contact dermatitis. Previously, we have shown that dermal exposure of female and male B6C3F1 mice to 5% MWFs for three months resulted in accumulation of mast cells and elevation of histamine in the skin. Topical exposure to MWFs also resulted in elevated oxidative stress in the liver of both sexes and the testes in males. The goal of this study was to evaluate whether oxidative stress in the skin exacerbated mast cell influx after MWF treatment. Oxidative stress in skin of B6C3F1 mice was generated by vitamin E deprivation. Mice were given vitamin E deficient or basil diets for 34 weeks. [Description provided by NIOSH]
• Subjects:
  Dermatitis Metals Occupational Exposure Occupational Health Safety
• Keywords:
  Metalworking-fluids Occupational-exposure Occupational-hazards Occupational-health
• ISSN:
  1096-6080
• Publisher:
  Oxford University Press
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; OSHA Region 3 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  60
• Volume:
  60
• Issue:
  1
• NIOSHTIC Number:
  nn:20021451
• Citation:
  Toxicologist 2001 Mar; 60(1):60
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 40th Annual Meeting, March 25-29, 2001, San Francisco, California
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f213795852712ffa485f4078352d611d9f88a77219b0bce054526931747f178df5d4005b6d0c8d13050c5989732ff248129e2fc70e26faa23cdf9523974346af
• Download URL:
  https://stacks.cdc.gov/view/cdc/198762/cdc_198762_DS1.pdf
• File Type:
  [PDF - 129.78 KB ]