A Model for Controlling and Quantifying Volitional Muscle Performance of Rat Plantar Flexors In Vivo

Details

• Personal Author:
  Cutlip, Robert G. ; Shastri V ; Wirth, Oliver
• Description:
  An in vivo animal model was developed to study the effects of volitional, eccentric, concentric, and isometric muscle actions and varying work-rest cycles on muscle performance, behavior, and histological and biochemical response. Using a custom-designed apparatus that was attached to a standard operant chamber, rats were operantly conditioned with food rewards to perform a voluntary lifting task to generate controlled movement of the plantar flexors. An opening in the front panel of the operant chamber allowed the rat to enter a Plexiglass tube that was mounted vertically to restrict the movement of the rat. A load cell was embedded in a platform at the bottom of the tube to measure they dynamic force exerted by the plantar flexors. Inside the tube, a neck ring was supported by a yoke that moved along two vertical shafts via linear bearings. A displacement transducer (LVDT) was attached to the weight pans to measure the range of motion on the lift, and allowed determinations of velocity and acceleration of the lifting motion. [Description provided by NIOSH]
• Subjects:
  Animals Biochemistry Laboratories Musculoskeletal System Occupational Health Safety
• Keywords:
  Acceleration Animal-studies Biochemical-tests In-vivo-studies Laboratory-animals Muscles
• ISSN:
  0195-9131
• Publisher:
  Lippincott, Williams, and Wilkins
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  33
• Issue:
  5
• NIOSHTIC Number:
  nn:20021445
• Citation:
  Med Sci Sports Exerc 2001 May; 33(5)(Suppl 1):S295
• Editor(s):
  Raven PB
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Research Tools and Approaches
• Peer Reviewed:
  False
• Source Full Name:
  Medicine and Science in Sports and Exercise
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a229d45e18b87fe0995593d03c4a434b9f75ad2061e6975ff6dc19517c135e6905fc4e1c23e0890287a26a4fe4c30db0199ec9860307840a516b4a8954924fa2
• Download URL:
  https://stacks.cdc.gov/view/cdc/198759/cdc_198759_DS1.pdf
• File Type:
  [PDF - 37.23 KB ]