Role of Polychlorinated Biphenyl Exposure in the Progression of Neoplasia

Details

• Personal Author:
  Sargent LM
• Description:
  Progression is the conversion of initiated and promoted cells into cancer cells. This stage of neoplasia is characterized by an increased growth rate, metastasis, aneuploidy and evolving karyoptic instability. The stage of progression has been examined in experimental models of skin and liver cancer. Early experiments of multistage epidermal carcinogenesis demonstrated that neoplasms occur at a high frequency when complete carcinogens are applied chronically (Shubik et al., 1950). In the skin model, it was demonstrated that chronic application of an initiator to mouse skin shortened the latency to neoplasia (Roe et al., 1972; Hennings, et al., 1985). The stage of progression in liver cancer has been examined by an initiation-promotion-initiation protocol (IPI) that was first suggested by Potter (1981) and later demonstrated experimentally by Scherer (1984). In the rat liver model, the transition from preneoplastic to tumor is characterized by the appearance of foci in foci, increated chromosome damage (Pitot et al., 1989, Pitot, et al., 1991; Dragan et al., 1993; Sargent et al., 1996), and increased incidence of carcinomas (Scherer, et al., 1984; Reddy, et al., 1982). [Description provided by NIOSH]
• Subjects:
  Animals Carcinogens Environmental Monitoring Laboratories Liver Neoplasms Occupational Health Polychlorinated Biphenyls Respiratory Tract Diseases Safety Skin Skin Diseases

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• Keywords:
  Animal-studies Cancer Carcinogenesis Carcinogenicity Exposure-assessment Exposure-levels Laboratory-animals Liver-cancer Models Polychlorinated-biphenyls Pulmonary-system-disorders Respiratory-system-disorders Skin-cancer

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• ISBN:
  0813122260
• Publisher:
  The University of Kentucky Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Kentucky ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  373-379
• NIOSHTIC Number:
  nn:20021431
• Citation:
  PCBs. Robertson LW, Handsen LG, eds. Lexington, KY: The University of Kentucky Press, 2001 Jan; :373-379
• Contact Point Address:
  Dr. Linda M. Sargent, NIOSH, MS-3014, 1095 Willowdale Road, Morgantown, WV 26505, USA
• Email:
  lqs1@cdc.gov
• Editor(s):
  Robertson LW; Hansen LG
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  PCBs
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b9c04e49042e06557f601151eb5dd37584d70b8edba058c38987ac5ed65bcc4d6123ea9efa97b5d2c2c407d4ca4c0fcc93aaccc1bf56b8f4b9f6cc889e667e98
• Download URL:
  https://stacks.cdc.gov/view/cdc/198747/cdc_198747_DS1.pdf
• File Type:
  [PDF - 268.22 KB ]