Effects of Varying Work-Rest Cycles of Downhill Running on Acute Muscle Injury in Rats

Details

• Personal Author:
  Cutlip, Robert G. ; Cyphers D ; Garuccio C ; Miller R ; Park J ; Robertson A ; Wirth, Oliver
• Description:
  Four groups of six untrained rats were induced to run by mild electrical stimulation on a motorized treadmill at a speed of 16 m/min for a total 30 min. The treadmill was declined to 16 degrees to eccentrically bias contractions of the soleus muscle in the hind limbs. Rats in one group ran continuously for 30 min, while rats in the other three groups ran six 5-min bouts separated by rest periods of various durations. Rest durations of 2 min, 4 min, and 6 min were studied across these groups. One group of six sham-control rats were placed in the treadmill chamber with a nonmoving belt and active shock grid for 30 min. All rats conformed to the running task quickly and received only a few shocks during the first few minutes of the protocol. Rats were sacrificed 48 hr following exercise. Histological and enzyme assay tecniques were used to assess acute muscle injury. Results showed that 30 min of continuous downhill running produced visible signs of injury and inflammation in the soleus. Less injury was found in conditions with intermittent rest periods, and no visible signs of injury or inflammation were found with the longer rest durations. Results of the present investigation suggest that intermittent rest periods provide a protective effect against acute muscle injury, and provide evidence that a rodent treadmill model may be a useful model for the study of musculoskeletal injury and the effects of various exercise and work practices. [Description provided by NIOSH]
• Subjects:
  Animals Histology Laboratories Musculoskeletal Diseases Musculoskeletal System Occupational Health Safety
• Keywords:
  Aerobic-metabolism Animal-studies Injuries Laboratory-animals Muscle-function Muscle-stress Muscle-tension Muscle-tissue Muscular-disorders Musculoskeletal-system Musculoskeletal-system-disorders Rest-periods

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• ISSN:
  0195-9131
• Publisher:
  Lippincott Williams & Wilkins
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  33
• Issue:
  5
• NIOSHTIC Number:
  nn:20021410
• Citation:
  Med Sci Sports Exerc 2001 May; 33(5)(Suppl 1):S121
• Editor(s):
  Raven PB
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  Medicine and Science in Sports and Exercise
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:5b4fa28272e921088f989abfb9ce7dbee58c12fe3897fcf410666cde1e5e782adfed7bfbfce91d82e0918c7e3ac4d57648e689491c54e30feaddfbd8eab451c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/198738/cdc_198738_DS1.pdf
• File Type:
  [PDF - 36.89 KB ]