How Gas Trapping at Low Lung Volumes Affect Energy Required to Expand Lung to Total Lung Capacity?

Details

• Personal Author:
  Frazer D ; Friend KA ; Goldsmith T ; McKinney W ; Tomblyn S
• Description:
  When an excised lung is slowly ventilated, not all gas entering the lung during inflation can be removed during the following lung deflation. In order to develop a realistic model of the gas trapping process, it is important to determine the mechanical characteristics of the region of the lung where gas trapping takes place. In this study, excised rat lungs were inflated-deflated from the degassed state for two cycles between 30 cm H2O, defined as total lung capacity (TLC), and a minimum pressure of -5 cm H2O (PLmin). Then the lungs were ventilated between 60% TLC and PLmin at a slow continuous rate for 10 inflation deflation cycles. During this procedure, trapped gas accumulated in the lungs. The lung were then inflated to TLC and the increase in energy necessary to expand the lung compared to the second inflation-deflation cycle was determined. Results show that a significant increase in energy was required to expand the lungs containing trapped gas which accumulated as the lung was ventilated at low lung volumes when compared with the energy required to expand the lung during the second inflation-deflation cycle. [Description provided by NIOSH]
• Subjects:
  Animals Laboratories Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety
• Keywords:
  Animal Studies Gases In Vitro Study Laboratory Animals Lung Burden Lung Disorders Models
• ISSN:
  0090-6964
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  29
• NIOSHTIC Number:
  nn:20021308
• Citation:
  Ann Biomed Eng 2001 Oct; 29(Suppl 1):S143
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  False
• Source Full Name:
  Annals of Biomedical Engineering
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:522d327ce6057fd25d22041a7dff2677676ecbb59f1a2936b9b67f69a66a1450b34506682265cc1d34314fca7e238ac64227dbaf08eb9e08c4f3767785216a61
• Download URL:
  https://stacks.cdc.gov/view/cdc/198686/cdc_198686_DS1.pdf
• File Type:
  [PDF - 103.96 KB ]