Immunotoxicology: Effects of, and Response to, Drugs and Chemicals

Details

• Personal Author:
  Dean JH ; House RV ; Luster MI
• Description:
  The immune system is a complex, multi-cellular organ system consisting of granulocytes, macrophages, lymphocytes, and dentritic cells with various functions and phenotypic characteristics, as well as various soluble mediators. These cells of hemopoietic origin are found in the peripheral blood, lymphatic fluid, and organized lymphoid tissues, including bone marrow, spleen, thymus, lymph nodes, tonsils, and mucosa-associated lymphoid tissue. The immune system is in a constant state of self-renewal involving cell proliferation , differentiation, and maturation. It exists to defend the body against invasion by infectious and opportunistic microorganisms, and spontaneously arising neoplasms. This network of cells and soluble factors is highly regulated and interdependent, must discriminate self from non-self, and can react to non-self with many different (pleiotropic) defensive responses (81). [Description provided by NIOSH]
• Subjects:
  Blood Communicable Diseases Immune System Lymphatic System Microbiology Neoplasms Occupational Health Safety
• Keywords:
  Bone Marrow Cell Differentiation Immune System Immunotoxins Infectious Diseases Lymphatic System Lymph Nodes Lymphocytes Microorganisms Spleen Disorders
• ISBN:
  1560328142
• Publisher:
  Taylor & Francis
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20021287
• Citation:
  Principles and methods of toxicology, 4th edition. Hayes AW, ed. Philadelphia, Pennsylvania: Taylor & Francis, 2001 Jan; :1415-1450
• Editor(s):
  Hayes AW
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  Principles and methods of toxicology, 4th edition
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:7d43480f1c0879fbd1f5439bffbe81a0874b0548f639d9cc9b4ee685be6b446e55a597ba34188704dc618699d139cdbfb13d8ae3a432328849ba57aae3d4f1f4
• Download URL:
  https://stacks.cdc.gov/view/cdc/198675/cdc_198675_DS1.pdf
• File Type:
  [PDF - 1.55 MB ]