Effect of Metabolic Polymorphisms on Benzidine-Induced Bladder Cancer in Chinese Workers: A Nested Case-Control Study

Details

• Personal Author:
  Bell DA ; Boissy R ; Carreon T ; Feng P ; Grant DJ ; Hayes RB ; Hemstreet GP ; Kadlubar FF ; Lemasters GK ; Li G ; Rothman N ; Ruder, Avima M. ; Schulte, Paul A. ; Yin S
• Description:
  Slow acetylation activity and its associated NAT2 genotype are generally associated with increased risk for bladder cancer in general populations and in workers exposed to arylamine mixtures. For workers exposed to benzidine, a borderline protective association has been reported. The purpose of this study was to evaluate the impact that metabolic polymorph isms have on bladder cancer in Chinese workers exposed only to benzidine. This nested case-control study included 30 cases with transitional cell carcinoma of the urinary bladder, diagnosed after 1991. Sixty seven controls, frequency-matched by decade of birth, were selected. NAT2 and CYP 1 A2 enzymatic activities were characterized by measuring urinary caffeine metabolite ratios as phenotypic function markers. Polymerase chain reaction-based methods were used to identify genotypes for the following genes: NAT2, NAT1, GSTM1, GSTT1, GSTP1, and UGTIA1. Crude analysis of bladder cancer risk shows an odds ratio of 0.1 (95% confidence interval: 0.01 - 0.92) for workers with the NAT2 slow genotype. Adjustment for lifetime smoking, age, and NATI genotype did not alter the findings. A protective but not significant association was found for slow acetylation phenotype. NATl, GSTMl, and GSTTI polymorphisms showed no association with bladder cancer risk; frequencies of the rare alleles for GSTP 1 and UGT1A1 were too low for analysis. These findings suggest that the risk of bladder cancer from benzidine exposure is due to activation by N-acetylation. [Description provided by NIOSH]
• Subjects:
  Benzidines Environmental Exposure Occupational Exposure Occupational Health Risk Assessment Safety
• Keywords:
  Arylamines Bladder Cancer Bladder Disorders Endocrine System Disorders Exposure Assessment Exposure Levels Occupational Exposure Risk Analysis
• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies ; EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  153
• Issue:
  11
• NIOSHTIC Number:
  nn:20021273
• Citation:
  Am J Epidemiol 2001 Jun; 153(11)(Suppl):S199
• CAS Registry Number:
  4,4'-Diaminodiphenyl (CAS RN 92-87-5)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Epidemiology
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e8b3835fb2c365b11d9688ce982f86e7bd3394d68598f4894e64e4622eae9db3104e744e8f7ec7f81e5bed71f60136cd5bcf5422eb98bf3345ea37b2b0cad4d3
• Download URL:
  https://stacks.cdc.gov/view/cdc/198670/cdc_198670_DS1.pdf
• File Type:
  [PDF - 97.49 KB ]