Molecular Targeting of Nuclear Transcriptional Regulators

Details

• Personal Author:
  Dokka S ; Faroonsargn D ; Luo Q ; Rojanasakul Y ; Shi X ; Ye J
• Description:
  Gene regulation by nuclear transcription factors involves intracellular interactions of nuclear transcriptors with specific transport carriers and/or DNA regulatory elements using sequence-specific recognition sites. In this study, we utilized a series of synthetic peptides carrying the nuclear localization sequence of the transcriptor NF-KB p50 and p65 subunits to inhibit NF-KB-mediated gene expression. Gene transfection and gel-shift assays showed that these peptides were effective in inhibiting the nuclear translocation and transcriptional activation of NF-KB. However, their effects required the presence of a cell-permeable peptide which is covalently linked to the inhibitory peptides. These hybrid peptides may be used as novel therapeutic agents in diseases whose etiology is dependent on NF-KB activation. [Description provided by NIOSH]
• Subjects:
  Genetics Occupational Health Safety
• Keywords:
  Genes Therapeutic Agents Treatment
• ISBN:
  9780841236257
• Publisher:
  American Chemical Society
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  District of Columbia ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  193-200
• NIOSHTIC Number:
  nn:20021055
• Citation:
  Controlled Drug Delivery: Designing Technologies for the Future. American Chemical Society (ACS) Symposium Series 752. Park K, Mrsny RJ, eds. Washington, DC: American Chemical Society, 2000 May; :193-200
• Editor(s):
  Park K; Mrsny RJ
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  False
• Source Full Name:
  Controlled Drug Delivery: Designing Technologies for the Future. American Chemical Society (ACS) Symposium Series 752
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f2a1e652b2396260ee798fce5ec45770467ae0516cb86490ba2829433e7f320d359079158649bf3cf92d3607179822b4d8446ef55cf97d54af08b59015dfd396
• Download URL:
  https://stacks.cdc.gov/view/cdc/198627/cdc_198627_DS1.pdf
• File Type:
  [PDF - 645.89 KB ]