Differential Ability of Transitional Metals to Induce Pulmonary Inflammation

Details

• Personal Author:
  Antonini JM ; Clarke RW ; Godleski JJ ; Hauser R ; Paulauskis JD ; Rice TM
• Description:
  Transition metals are components of airborne particles and have been implicated in adverse health effects. Relative toxicity and inflammatory potential of these metals are usually inferred from separate studies since little directly comparable data are available. The objective of this study was to compare the pulmonary effects of intratracheally-instilled, equimolar. soluble forms of six metal sulfates. Rats received either phosphate-buffered saline. 0.1 umol/kg, or 1.0 umol/kg of vanadium. nickel, iron (II), copper, manganese, or zinc. Bronchoalveolar lavage was performed at 0, 4, 16, or 48 hrs post-installation. At the 0.1 umol/kg dose, only Cu induced significant neutrophil influx at 16 and 48 hrs (p<0.05). For the 1.0 umol/kg dose at 4 hrs, Cu and Fe(II)-exposed animals had a significant increase in percent neutrophils compared to saline controls, and Cu had a significantly higher percentage than all other metals. After 16 hrs, each metal tested induced significant neutrophilia compared to controls, and Cu and Mn induced significantly higher neutrophilia than the other metals. At 48 hrs, neutrophilia was still increased in all metal exposures except Fe(II). Interestingly, Mn was the only metal to induce a significant increase in eosinophils (16 hr post-instillation, p<0.05). Additionally, Cu and Ni-exposed rats had significantly higher levels of lactate dehydrogenase in lavage supernatant compared to the other metals and controls. These results indicate that transition metals differ in their ability to induce pulmonary inflammation and toxicity. Cu appears to be the most pro-inflammatory metal, followed by Mn and Ni, while V, Fe(II), and Zn induced similar levels of neutrophilia. We conclude that the extent and cellular nature of metal-induced pulmonary inflammation depends on the individual metal. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Animals Environmental Exposure Hazardous Substances Laboratories Lung Diseases Metals Occupational Health Respiratory Tract Diseases Safety
• Keywords:
  Airborne Particles Animal Studies Exposure Levels Health Hazards Laboratory Animals Metal Compounds Pulmonary System Disorders Respiratory System Disorders Toxic Effects
• ISSN:
  1096-6080
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Massachusetts ; OSHA Region 1 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  36
• Volume:
  54
• Issue:
  1
• NIOSHTIC Number:
  nn:20021053
• Citation:
  Toxicologist 2000 Mar; 54(1):36
• CAS Registry Number:
  Copper (CAS RN 7440-50-8) ; Iron (CAS RN 7439-89-6) ; Manganese (CAS RN 7439-96-5) ; Nickel (CAS RN 7440-02-0) ; Vanadium (CAS RN 7440-62-2) ; Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  False
• Source Full Name:
  The Toxicologist. Society of Toxicology 39th Annual Meeting, March 19-23, 2000, Philadelphia, Pennsylvania
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:30fd23845e9077157cfad3eed991a4211a0cd7f4566a7494c5f7be5de1664fff9893af4a74f9b798e769315cb3f59c1a38854611b456fa3651c2e9770858827a
• Download URL:
  https://stacks.cdc.gov/view/cdc/198625/cdc_198625_DS1.pdf
• File Type:
  [PDF - 79.27 KB ]