Genetic Engineering and Molecular Technology

Details

• Personal Author:
  Bolon BD ; Galbreath E ; Sargent L ; Weiss J
• Description:
  Scientists have been performing genetic manipula­tions and analyses since Mendel first reported the heritable nature of physical characteristics in pea plants in 1865. With respect to rats, experimental biologists who crossbred rat strains for a variety of traits (Chapter 1) were occasionally rewarded by the advent of an unexpected functional or structUral phenotype. Such serendipitously acquired mutant lines, most of which result froT a spontaneous mutation to a single gene, were often expanded and characterized to serve as animal models of human diseases. However, a large-scale random breeding program to produce new lines with novel mutations would be very costly in rodents, even if combined with treatments that accelerate the muta­tion rate (e.g. Kasarkis et al., 1998). Furthermore, random breeding schemes and mutagenic agents cannot be employed effectively to produce defects in specific genes of interest. [Description provided by NIOSH]
• Subjects:
  Animals Genetics Laboratories Occupational Health Safety
• Keywords:
  Animal Studies Genes Genetic Engineering Genetic Factors Laboratory Animals Molecular Biology
• ISBN:
  012426400X
• Publisher:
  Academic Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20020895
• Citation:
  The laboratory rat. Krinke GJ, Bullock G, Bunton T, eds. London: Academic Press, 2000 Jun; :603-633
• Editor(s):
  Krinke GJ; Bullock G; Bunton T
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  False
• Source Full Name:
  The laboratory rat
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:209ed87e3806213e67055e7b5a3f0d4368f05ec71a814373789215356ede4e829b838fd14b00239fb9b9eaf97d1e337ea0489566adcb564a4e7a96935a6a0efc
• Download URL:
  https://stacks.cdc.gov/view/cdc/198543/cdc_198543_DS1.pdf
• File Type:
  [PDF - 1.01 MB ]