Human Health Effects After Exposure to 2,3, 7,8-TCDD

Details

• Personal Author:
  Mocarelli P ; Sweeney, Marie H.
• Description:
  In 1949, the first descriptions of human exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD)-contaminated chemicals were reported after a trichlorophenol reactor explosion in Nitro, West Virginia, USA. Reported non-cancer health effects included a range of conditions affecting most systems. Additional reports of the health consequences of exposure continued through the remainder of the century. The majority of effects have been reported among highly exposed groups including occupational populations, such as chemical production workers, pesticide applicators, and individuals who handled or were exposed to materials treated with 2,3,7,8-TCDD-contaminated pesticides, and among residents of communities contaminated with tainted waste oil (Missouri, USA) and industrial effluent (Seveso, Italy). For only six exposed populations were biological measurements of 2,3,7,8-TCDD-contaminated collected and used to examine the relationship between non-cancer health effects and exposure. Of the many non-cancer health effects thought to be associated with 2,3,7,8-TCDD exposure, only chloracne, elevations in GGT and triglyceride levels, and alterations in FSH and LH were related to serum 2,3,7,8-TCDD levels. Mortality from cardiovascular diseases also appeared to be elevated among cohorts of exposed chemical workers and Seveso residents. Continued surveillance of the health of exposed populations will be useful in identifying the long-term effects of both high and low 2,3,7,8-TCDD exposure. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Cardiovascular Diseases Cardiovascular System Environmental Exposure Immune System Insecticides Mortality Occupational Exposure Occupational Health Safety Skin Skin Diseases

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• Keywords:
  Air Contamination Author Keywords: Cardiovascular Disease Cardiovascular Disease Cardiovascular System Disease Chloracne Exposure Levels Hormonal Alterations Immune Effects Immune System Disorders Liver Effects Mortality Data Mortality Rates Neurological Diseases Neurological Effects Occupational Exposure Pesticide Residues Pesticides Skin Disorders Skin Lesions

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• ISSN:
  0265-203X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  303-316
• Volume:
  17
• Issue:
  4
• NIOSHTIC Number:
  nn:20020827
• Citation:
  Food Addit Contam 2000 Apr; 17(4):303-316
• Contact Point Address:
  National Institute for Occupational Safety and Health, Education and Information Division, Mailstop C-32, 4676 Columbia Parkway, Cincinnati, OH 45226-1988, USA
• Email:
  mhs2@cdc.gov
• CAS Registry Number:
  2,3,7,8-Tetrachlorodibenzo-p-dioxin (CAS RN 1746-01-6)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Food Additives and Contaminants
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:e56e3631e159a3eeeddbce60ca76f217e5021dac309527569331efa11b4324058fb4e0ed8fe97234acf0639cc92c1ee4f60210ef32e082cf146b76f6e0857868
• Download URL:
  https://stacks.cdc.gov/view/cdc/198489/cdc_198489_DS1.pdf
• File Type:
  [PDF - 436.59 KB ]