Association Between GSTM1*0 and Squamous Dysplasia of the Esophagus in the High Risk Region of Linxian, China

Details

• Personal Author:
  Dawsey SM ; Frye BL ; Olivero OA ; Poirier MC ; Ratnasinghe D ; Roth MJ ; Tangrea JA ; Taylor, Philip R. ; Wang GQ ; Weston A ; Woodson KG ; Zhou B
• Description:
  Individuals with specific phase I and phase II enzyme polymorphisms may be at increased risk for squamous cell carcinoma of the esophagus. However, to our knowledge there has been only one previous report that evaluates a potential role for these polymorphisms in increasing risk for preneoplastic squamous lesions of the esophagus. To explore this further, we examined polymorphisms in CYP1A1, CYP2E1, GSTM1 and GSTT1, both independently and in combination, for potential associations with the risk of biopsy-proven squamous dysplasia of the esophagus in asymptomatic adults from Linxian, a high risk region in China. Cases consisted of 56 individuals from an esophageal cancer screening study with an endoscopic biopsy diagnosis of mild or moderate squamous dysplasia. Each case was matched on age (+/- 1 year) and gender to a control. Controls were defined as screening study participants with an endoscopic biopsy diagnosis of normal mucosa or esophagitis. DNA was extracted from frozen cell samples obtained by cytologic balloon examination and genotyped using standard methods. Individuals who were GSTM1 null (homozygous for GSTM1*0) were found to have a tendency for an increased risk of esophageal squamous dysplasia (odds ratio=2.6, 95% CI, 0.9-7.4). No excess risks were observed for inheritance of other putative at risk genotypes CYP1A1*2B, CYP2E1*6 or GSTT1*0. The risk associated with the inheritance of combined genotypes was not significantly different than the risk estimates from the univariate analysis. These results are consistent with the notion that exposure to environmental carcinogens that are detoxified by GSTM1, such as polycyclic aromatic hydrocarbons, may contribute to the etiology of esophageal cancer in Linxian. [Description provided by NIOSH]
• Subjects:
  Age Factors Carcinogens Demography Environmental Exposure Enzymes Epidemiology Hydrocarbons Neoplasms Occupational Health Polycyclic Aromatic Hydrocarbons Risk Assessment Risk Factors Safety Sex Characteristics

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• Keywords:
  Age Factors Author Keywords: Esophageal Cancer Cancer Carcinomas China Cytochrome P450 Demographic Characteristics Environmental Exposure Glutathione-S-transferase Polycyclic Aromatic Hydrocarbons Risk Analysis Risk Factors Sex Factors Statistical Analysis

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• ISSN:
  0304-3835
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Maryland ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  73-81
• Volume:
  156
• Issue:
  1
• NIOSHTIC Number:
  nn:20020798
• Citation:
  Cancer Lett 2000 Aug; 156(1):73-81
• Contact Point Address:
  Suite 321, 6006 Executive Boulevard MSC 7058, Bethesda, Maryland 20892-7058, USA
• Email:
  mr166@nih.gov
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Cancer Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8c1f4d8880153c23b560dddfed725342a13a1700b3cf0eea0fffc05660f119bec84eb6094dbacef301224f13733e743b00a28615f9c4e0811958c0f9d8c9fdc1
• Download URL:
  https://stacks.cdc.gov/view/cdc/198463/cdc_198463_DS1.pdf
• File Type:
  [PDF - 102.97 KB ]