Prioritization of NTP Reproductive Toxicants for Field Studies

Details

• Personal Author:
  Ahlers HW ; Chapin RE ; Daston GP ; Foster PMD ; Kavlock RJ ; Moorman WJ ; Morawetz, John S. ; Schnorr, Teresa M. ; Schrader, Steven M.
• Description:
  Population studies that evaluate human reproductive impairment are time consuming, expensive, logistically difficult, and with limited resources must be prioritized to effectively prevent the adverse health effects in humans. Interactions among health scientists, unions, and industry can serve to identify populations exposed to potential hazards and develop strategies to evaluate and apply appropriate controls. This report describes a systematic method for prioritizing chemicals that may need human reproductive health field studies. Rodent reproductive toxicants identified from the National Toxicology Program (NTP) Reproductive Assessment by Continuous Breeding (RACB) protocol were prioritized on the basis of potency of toxic effect and population at risk. This model for prioritization links NTP findings with data from the National Occupational Exposure Survey (NOES) and the Hazardous Substance Data Base (HSDB) or the High Production Volume Chemical Database (HPVC) to prioritize chemicals for their potential impact on worker populations. The chemicals with the highest priority for field study were: dibutyl phthalate, boric acid, tricresyl phosphate, and N,N-dimethylformamide. [Description provided by NIOSH]
• Subjects:
  Chemistry Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Author Keywords: Prioritization Chemical Analysis HSDB NOES NTP RACB Reproduction Reproductive Effects Reproductive Hazards Reproductive System Reproductive System Disorders Reproductive Toxicants

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• ISSN:
  0890-6238
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DART - Division of Applied Research and Technology ; EID - Education and Information Division ; DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  293-301
• Volume:
  14
• Issue:
  4
• NIOSHTIC Number:
  nn:20020760
• Citation:
  Reprod Toxicol 2000 Jul-Aug; 14(4):293-301
• Contact Point Address:
  National Institute for Occupational Safety and Health (NIOSH), 4676 Columbia Pkwy, Cincinnati OH, 45226, USA
• Email:
  wmj2@cdc.gov
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Reproductive Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:42f261c7d92a834e9141d5d9d45b974704a42c2fafb8c231f90a7fdd28e1bbc23547927249c3f7d0ee8dfac5dcb7209464769873e36e526dda0274e68eebed00
• Download URL:
  https://stacks.cdc.gov/view/cdc/198428/cdc_198428_DS1.pdf
• File Type:
  [PDF - 102.75 KB ]