Diesel Exhaust Exposure and Lung Cancer: Adjustment for the Effect of Smoking in a Retrospective Cohort Study

Details

• Personal Author:
  Garshick E ; Larkin EK ; Rosner B ; Smith, Thomas J. ; Speizer FE ; Stayner, Leslie T.
• Description:
  The extent that cigarette smoking may confound the relationship between diesel exhaust exposure and lung cancer was assessed in a retrospective cohort study of 55,395 U.S. railroad workers followed from 1959 to 1976. The relative risk (RR) of lung cancer due to diesel exhaust was indirectly adjusted using job-specific smoking data from a case-control study of railroad workers who died between 1981-1982 and from a survey of 514 living workers from an active railroad in 1982. Adjustment factors were developed based on the distribution of job-specific smoking rates. The unadjusted RR for lung cancer was 1.58 (95% CI = 1.14-2.20) for workers aged 40-44 in 1959, who experienced the longest possible duration of exposure, and the smoking adjusted RR was 1.44 (1.01-2.05). After considering differences in smoking rates between workers exposed and unexposed to diesel exhaust in a relatively large blue-collar cohort, there were still elevated risks of lung cancer in workers in jobs with diesel exhaust exposure. [Description provided by NIOSH]
• Subjects:
  Demography Lung Lung Diseases Neoplasms Occupational Health Railroads Respiratory System Respiratory Tract Diseases Safety Smokers Tobacco Products Vehicle Emissions

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• Keywords:
  Author Keywords: Confounding Cigarette Smoking Demographic Characteristics Diesel Emissions Diesel Exhaust Diesel Exhausts Lung Cancer Lung Disorders Lung Function Pulmonary System Disorders Railroad Industry Railroad Workers Respiratory System Disorders Smoking Statistical Analysis

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; Ohio ; OSHA Region 1 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  EID - Education and Information Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  399-409
• Volume:
  38
• Issue:
  4
• NIOSHTIC Number:
  nn:20020727
• Citation:
  Am J Ind Med 2000 Oct; 38(4):399-409
• Contact Point Address:
  Eric Garshick, MOH Medical and Research Service, VA Boston Health Care Systems, 1400 UFW Parkway, Boston, MA 02132
• Email:
  eric.garshick@med.va.gov
• Federal Fiscal Year:
  2001
• NORA Priority Area:
  Work Environment and Workforce: Mixed Exposures
• Performing Organization:
  Harvard Medical School, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19990930
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20020929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:fb086233d1aa30d9f5e1e30f3bf95a2edfa4ee82ea2f195d80f9bbb033bac164da49d015fc7c5b1ac32a47090b75b58713ca4ddd7549e90e57c0c93e6111fe5c
• Download URL:
  https://stacks.cdc.gov/view/cdc/198400/cdc_198400_DS1.pdf
• File Type:
  [PDF - 138.34 KB ]