Oxidative Signaling Pathway for Externalization of Plasma Membrane Phosphatidylserine During Apoptosis

Details

• Personal Author:
  Fabisiak JP ; Kagan VE ; Kawai K ; Schor NF ; Shvedova AA ; Tyurin VA ; Tyurina YY
• Description:
  Active maintenance of membrane phospholipid asymmetry is universal in normal cell membranes and its disruption with subsequent externalization of phosphatidylserine is a hallmark of apoptosis. Externalized phosphatidylserine appears to serve as an important signal for targeting recognition and elimination of apoptotic cells by macrophages, however, the molecular mechanisms responsible for phosphatidylserine translocation during apoptosis remain unresolved. Studies have focused on the function of aminophospholipid translocase and phospholipid scramblase as mediators of this process. Here we present evidence that unique oxidative events, represented by selective oxidation of phosphatidylserine, occur during apoptosis that could promote phosphatidylserine externalization. We speculate that selective phosphatidylserine oxidation could affect phosphatidylserine recognition by aminophospholipid translocase and/or directly result in enzyme inhibition. The potential interactions between the anionic phospholipid phosphatidylserine and the redox-active cationic protein effector of apoptosis, cytochrome c, are presented as a potential mechanism to account for selective oxidation of phosphatidylserine during apoptosis. Thus, cytochrome c-mediated phosphatidylserine oxidation may represent an important component of the apoptotic pathway. [Description provided by NIOSH]
• Subjects:
  Enzymes Lipids Occupational Health Oxidants Safety
• Keywords:
  Oxidation Oxidative Phosphorylation Oxidative Processes Phospholipids
• ISSN:
  0014-5793
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; Pennsylvania ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  1-7
• Volume:
  477
• Issue:
  1
• NIOSHTIC Number:
  nn:20020712
• Citation:
  FEBS Lett 2000 Jul; 477(1-2):1-7
• Contact Point Address:
  Department of Environmental and Occupational Health, University of Pittsburgh, 260 Kappa Drive, RIDC Park, Pittsburgh, PA 15238, USA
• Email:
  kagan@pitt.edu
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  False
• Source Full Name:
  Federation of European Biochemical Societies Letters
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:185cc8431d3725aa590db3e5fc62bcd707421544206e515f706f7c32049e4a7a28d8755295e65559088e49f74904c184d66ed2290fb895539e074ea5c5b828c5
• Download URL:
  https://stacks.cdc.gov/view/cdc/198388/cdc_198388_DS1.pdf
• File Type:
  [PDF - 356.83 KB ]