Predisposing Factors in Occupational Lung Cancer: Inorganic Minerals and Chromium

Details

• Personal Author:
  Castranova, Vincent ; Ding M ; Shi X ; Vallyathan V
• Description:
  Reactive oxygen species (ROS) have been implicated in the pathogenesis of cancer. Inhalation of inorganic minerals such as asbestos and crystalline silica, and metals such as arsenic, beryllium, chromium, nickel, and vanadium, may promote directly and indirectly enhanced generation of ROS at a persistent level in concert with chronic inflammation. Perpetual ROS generation can cause specific molecular changes resulting in the activation or inactivation of transcription factors that may alter gene expression leading to cell proliferation, differentiation, and carcinogenesis. The mechanisms involved in the signal transduction leading to these processes are the subject of intense investigation. In this review, some of the recent findings from our laboratories concerning key molecular events elicited by asbestos, crystalline silica, and chromium are presented. These include genotoxicity, DNA damage, lipid peroxidation, activation of transcription factors activator protein-1 (AP-1) or nuclear factor kappa B (NF-kappaB), and p53 or k-ras gene alterations. From these studies, it is evident that ROS signaling is critical for the responses of cytokines, growth factors, and activation or inactivation of transcription factors that promote carcinogenesis. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Asbestos Carcinogens Chromium Dust Lung Lung Diseases Mutagens Neoplasms Occupational Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide

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• Keywords:
  Asbestos Dust Author Keywords: Occupational Cancer Cancer Epidemiology Carcinogenesis Chromium Chromium Compounds Gene Mutation Genotoxic Effects Inorganic Compounds Inorganic Minerals Lung Cancer Mutagenesis Occupational Diseases Occupational Health Pulmonary System Disorders Reactive Oxygen Species Respiratory System Disorders Silica Dusts Silicates

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• ISSN:
  0731-8898
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  129-138
• Volume:
  19
• Issue:
  12
• NIOSHTIC Number:
  nn:20020653
• Citation:
  J Environ Pathol Toxicol Oncol 2000 Jan; 19(1-2):129-138
• Contact Point Address:
  Val Vallyathan, Ph.D., Professor of Pathology, Centers for Disease Control and Prevention, NIOSH, 1095 Willowdale Road, Morgantown, WV 26505-2888
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Beryllium (CAS RN 7440-41-7) ; Chromium (CAS RN 7440-47-3) ; Nickel (CAS RN 7440-02-0) ; Quartz (SiO2) (CAS RN 14808-60-7) ; Vanadium (CAS RN 7440-62-2)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Environmental Pathology, Toxicology, and Oncology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:90bb1bd873ff6da58b5aac1a0165f6a08cb8a3b5f4be68b3a8612f3ecd1247fa5eeb3b45cc76bc11e15e27424bc8ab34fffd2ed2b4b90fc28eedfccc7d9ef31d
• Download URL:
  https://stacks.cdc.gov/view/cdc/198337/cdc_198337_DS1.pdf
• File Type:
  [PDF - 627.69 KB ]