Comparison of Solvents for Removing Pesticides from Skin Using an In Vitro Porcine Model

Details

• Personal Author:
  Boeniger, Mark F. ; Campbell JL ; Eiteman MA ; Smith MA ; Williams PL
• Description:
  This study compared four solvents (1-propanol, polyethylene glycol [avg. MW 400], 10% Ivory Liquid and water, and D-TAM) for their ability to remove selected pesticides from an in vitro porcine skin model using a solvent-moistened wipe. Wipes were performed 90 min after pesticide was applied to the skin. The four pesticides selected (glyphosate, alachlor, methyl parathion, and trifluralin) were chosen because of their differences in water solubility. This study also determined whether pretreatment of skin with a solvent prior to pesticide application would either increase or decrease recovery of the pesticide. Recovery efficiencies for all solvents and pesticides were affected by the amount of contaminant on the skin. Although pesticide recoveries from all four solvents were similar (range: 45-57%), on average 1-propanol had significantly higher recoveries, followed by soap and water. There was no significant difference between polyethylene glycol, and D-TAM. When skin was pretreated with any of the four solvents before pesticide application, the recoveries of the more water soluble compounds, glyphosate and alachlor, decreased. When pretreatment with solvent preceded application of trifluralin, the pesticide with the lowest water solubility, recoveries increased. 1-Propanol or soap and water were more effective in removing pesticides from skin than polyethylene glycol or D-TAM, but the amount of pesticide recovered from skin was affected by the chemical characteristics of the pesticide (such as water solubility) and the amount of pesticide originally on the skin. This study provides information useful to the interpretation of skin wipe sample results collected in field studies. [Description provided by NIOSH]
• Subjects:
  Insecticides Occupational Health Safety Skin Skin Absorption Solvents
• Keywords:
  Author Keywords: Dermal Contamination In Vitro In Vitro Study Pesticide Pesticides Sampling Sampling Methods Skin Absorption Wipe Test
• ISSN:
  0002-8894
• Document Type:
  Text
• Funding:
  Contract
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  82-88
• Volume:
  61
• Issue:
  1
• NIOSHTIC Number:
  nn:20020624
• Citation:
  Am Ind Hyg Assoc J 2000 Jan/Feb; 61(1):82-88
• Contact Point Address:
  206 Environmental Health Science, Environmental Health Bldg., University of Georgia, Athens, GA 30602
• CAS Registry Number:
  Alachlor (CAS RN 15972-60-8) ; Glyphosate (CAS RN 1071-83-6) ; Parathion-methyl (CAS RN 2Furfuryl alcohol (CAS RN 98-00-0)) ; Trifluralin (CAS RN 1582-09-8)
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Source Full Name:
  American Industrial Hygiene Association Journal
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1ebf8de656d0b995bc3d07e4c151346dd66c20089e483bbb0bfe1e78c681bdfb2afd3108edb84fb02d776fa2f57e55bea73f96d9dfccf07ec9f813193d47a457
• Download URL:
  https://stacks.cdc.gov/view/cdc/198321/cdc_198321_DS1.pdf
• File Type:
  [PDF - 446.53 KB ]