Evaluation of In Vitro Effects of 50 and 60 Hz Magnetic Fields in Regional EMF Exposure Facilities

Details

• Personal Author:
  Boorman GA ; Galvin MJ Jr. ; Lotz, W. Gregory ; Owen RD
• Description:
  A weak association between magnetic-field exposure and increased incidences of cancer has been reported. While alterations in cellular processes after in vitro magnetic-field exposures have also been reported to provide plausibility for this association, other laboratories have been unable to repeat the findings. As part of an accelerated electric- and magnetic-field (EMF) research program, the National Institute of Environmental Health Sciences with the Department of Energy identified the replication of the published positive effects as a priority. Regional EMF exposure facilities were established to investigate major in vitro effects from the literature. These included effects on gene expression, intracellular calcium, colony growth in soft agar, and ornithine decarboxylase activity. The laboratories that first reported these effects provided experimental protocols, cell lines, and other relevant experiment details. Regional facility studies included sham/sham exposures (no applied field in either chamber) and were done in a blinded fashion to minimize investigator bias. In nearly all experiments, no effects of magnetic-field exposure were found. The effort provided insight into dealing with the difficulty of replication of subtle effects in complex biological systems. Experimental techniques provided some clues for the differences in experimental results between the regional facility and the original investigator. Studies of subtle effects require extraordinary efforts to confirm that the effect can be attributed to the applied exposure. [Description provided by NIOSH]
• Subjects:
  Electricity Environmental Exposure Laboratories Neoplasms Occupational Health Safety
• Keywords:
  Cancer Electrical Fields Exposure Levels In Vitro Studies Laboratory Testing Magnetic Fields
• ISSN:
  0033-7587
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Georgia ; Maryland ; North Carolina ; Ohio ; OSHA Region 3 ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences ; OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  153
• Issue:
  5
• NIOSHTIC Number:
  nn:20020617
• Citation:
  Radiat Res 2000 May; 153(5)(Pt 2):648-657
• Contact Point Address:
  National Institute for Occupational Safety and Health (NIOSH), Division of Biomedical and Behavioral Sciences, 4676 Columbia Parkway, Cincinnati, Ohio 45226-1998
• Federal Fiscal Year:
  2000
• Peer Reviewed:
  True
• Part Number:
  2
• Source Full Name:
  Radiation Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4d5f3a74036dce2f3d5b0530b7bc5c1c2572345966a4e864c825942aae63a64a63bb53fdbc9145aa383475a261ab421fb1a89b0be1a1523e90df0581ca0466fd
• Download URL:
  https://stacks.cdc.gov/view/cdc/198314/cdc_198314_DS1.pdf
• File Type:
  [PDF - 291.88 KB ]