Reactive Oxygen Species in the Aerobic Decomposition of Sodium Hydroxymethanesulfinate

Details

• Personal Author:
  Gannett PM ; Makarov SV ; Mundoma C ; Shi X ; Simoyi RH ; Svarovsky SA
• Description:
  Sodium hydroxymethanesulfinate, (HOCH2SO2Na, HMS) is relatively stable in aqueous alkaline environments, but rapidly decomposes in acidic medium to give a variety of products that include sulfur dioxide. A detailed kinetic and mechanistic study of the decomposition of HMS in slightly acidic medium has shown a process that produces dithionite, S2O2-4, which is preceded by an induction period which persists for as long as molecular oxygen is present in the reaction solution. The complete consumption of molecular oxygen is a prerequisite for the formation of S2O2-4. Among some of the intermediates detected in the decomposition of HMS is the sulfite radical, SO-3. Comparisons are made between the decomposition mechanisms of thiourea dioxide (aminoiminomethanesulfinic acid) and HMS. [Description provided by NIOSH]
• Subjects:
  Acids Carcinogens Occupational Health Safety Sulfur Compounds Thiourea Toxicology
• Keywords:
  Acidity Aminoiminomethanesulfinic Acid Author Keywords: Hydroxymethanesulfinate Reactive Oxygen Species Sulfite Radical Ion Sulfoxylate Ion Sulfur-compounds Sulfur Dioxide Radical Ion Thioureas Thioureas Oxides Toxicopathology Tumorigenesis

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• ISSN:
  0003-9861
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  289-296
• Volume:
  367
• Issue:
  2
• NIOSHTIC Number:
  nn:20000968
• Citation:
  Arch Biochem Biophys 1999 Jul; 367(2):289-296
• Federal Fiscal Year:
  1999
• NORA Priority Area:
  Research Tools and Approaches: Cancer Research Methods
• Peer Reviewed:
  True
• Source Full Name:
  Archives of Biochemistry and Biophysics
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:92a586edc4bdad64326de1e46f1dda826785b482162818e6e3f94533d75dd9491de4c69fffd49abd592a4a955ae5197bfba647eea4443d6ea3649287ce863e96
• Download URL:
  https://stacks.cdc.gov/view/cdc/198280/cdc_198280_DS1.pdf
• File Type:
  [PDF - 240.07 KB ]