Discontinuous Lung Sounds and Hysteresis in Control and Tween 20-Rinsed Excised Rat Lungs

Details

• Personal Author:
  Cheng W ; DeLong DS ; Franz GN ; Frazer DG ; Petsonk, Edward L.
• Description:
  In the past, the relationship between pulmonary hysteresis and a model of the recruitment-derecruitment of lung units has been explored (Cheng, W., DeLong, D.S., Franz, G.N., Petsonk, E.L., Frazer, D.G., 1995, Resp. Physiol. 102, 205-215). The recruitment process is characterized by a sequence of events which represents discrete configurational changes in lung structure. It is assumed that energy released during the opening of lung units is associated with the formation of discontinuous lung sounds. The goal of this study was to record tracheal sounds for lungs inflated from different end-expiratory pressures and to relate the sound power to the normalized hysteresis of individual pressure-volume (PL-VL) loops. PL-VL curves and lung sounds were recorded for control lungs and lungs rinsed with Tween 20 in order to estimate the role of alveolar surfactant on the recruitment-derecruitment process. Results indicate that there may be two populations of lung units, one which is altered by Tween 20 and another which is not. The population not affected by Tween 20 appears to be responsible for producing discrete lung sounds and may represent the opening of larger conducting airways. The second population, possibly within the respiratory zone, is affected by alterations in surface tension and contributes to pulmonary hysteresis, but, apparently, does not contribute significantly to lung sound power measured at the trachea. [Description provided by NIOSH]
• Subjects:
  Lung Noise Noise, Occupational Occupational Health Respiratory System Safety
• Keywords:
  Author Keywords: Airways Closure Lung-function Lung Sounds Lung Units Mammals Mechanics Of Breathing Pressure-gradients Pressure-testing Rat Recruitment Sound Sound-analyzers Sounds

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• ISSN:
  0034-5687
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  131-140
• Volume:
  117
• Issue:
  2
• NIOSHTIC Number:
  nn:20000900
• Citation:
  Respir Physiol 1999 Sep; 117(2/3):131-140
• Federal Fiscal Year:
  1999
• NORA Priority Area:
  Other Occupational Concerns
• Peer Reviewed:
  True
• Source Full Name:
  Respiration Physiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ab0557c3e8051df3d71dd96f1949de810809f2939a02540e3bacec6497ee5a0ecf7ea507204b17e5285bf37e6297759de6bcef73e17db9a544ea1bc39241a9e7
• Download URL:
  https://stacks.cdc.gov/view/cdc/198245/cdc_198245_DS1.pdf
• File Type:
  [PDF - 301.18 KB ]