Validation

Details

• Personal Author:
  Perera FP ; Schulte, Paul A.
• Description:
  Biologic markers and the studies that include them need to be shown to have measurement, internal, and external validity before they can be used accurately in etiologic research and quantitative risk assessment. The use of invalid markers can result in nondifferential misclassifications of exposure or outcome, which can lead to underestimation of a true effect (Hogue and Brewster, 1988). Risk assessments based on studies that underestimate a true effect can lead to regulations that provide exposure limits that are thought to be "safe" but, in fact, are not. Conversely, a differential misclassification bias, depending on the direction of the bias, can lead to regulations that provide exposure limits that are either too high or too low. In quantitative risk assessment, the inferences derived from small study groups are generalized to larger populations. The strength of those inferences depends on the methodology of the study, including measurements and other design factors that lead to the results, Invalid measurements, inferences, or generalizations may lead to erroneous risk assessments. In this chapter, the three categories of validity are discussed in terms of how they apply to biologic markers for epidemiologic research and quantitative risk assessment. [Description provided by NIOSH]
• Subjects:
  Biochemistry Epidemiology Occupational Health Safety
• Keywords:
  Biochemical-markers Molecular-biology Molecular-epidemiology
• ISBN:
  9780126323450
• Publisher:
  Academic Press
• Document Type:
  Text
• Genre:
  Book
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  79-107
• NIOSHTIC Number:
  nn:20000087
• Citation:
  Molecular epidemiology: principles and practices. Schulte PA, Perera FP, eds. San Diego, CA: Academic Press, 1993 Apr; :79-107
• Editor(s):
  Schulte PA; Perera FP
• Federal Fiscal Year:
  1993
• Peer Reviewed:
  False
• Source Full Name:
  Molecular epidemiology: principles and practices
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c6c12f81175746b69a0b8785b543ff3012d3d2d9df2416f23554731be5a68a7c4e1d8841814f1faa4acee3c36a6630342d3afc9798559fd4d44a599126c8a4d9
• Download URL:
  https://stacks.cdc.gov/view/cdc/198149/cdc_198149_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]