Coplanar PCBs and the Relative Contribution of Coplanar PCBs, PCDDs, and PCDFs to the Total 2,3, 7,8-TCDD Toxicity Equivalents in Human Serum

Details

• Personal Author:
  Kang, Daehee ; Patterson DG Jr. ; Tepper, Allison L.
• Description:
  An analysis of the relative contribution of coplanar polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) to the total 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity equivalents (TEQs) in human serum was performed. Blood samples were collected from 46 males employed in a pulp and paper mill and 16 males living in the local community (controls). The samples were analyzed for serum 3,3',4,4'-tetrachlorobiphenyl (32598133) (PCB- 77), 3,3',4,4',5-pentachlorobiphenyl (57465288) (PCB-126), and 3,3',4,4',5,5'-hexachlorobiphenyl (32774166) (PCB-169) and unspecified PCDDs and PCDFs. TEQs were calculated from the data using approaches described by Safe and the World Health Organization (WHO). PCB-126 and PCB-169 were detected in 94 to 98% of all serum samples. PCB-77 was not detected. The mean serum PCB-126 and PCB- 169 concentrations were higher in the pulp and paper mill workers than in the controls, 25 versus 18 nanograms per kilogram (ng/kg) and 36 versus 27ng/kg, respectively. The difference in PCB-126 concentrations between the two groups was statistically significant whereas that of PCB-169 was not. Serum PCB-126 concentrations were significantly, positively correlated with the BMI. Serum PCB-169 concentrations were significantly, positively correlated with age. Neither PCB-126 nor PCB-169 concentrations were significantly associated with alcohol or local fish consumption. Serum PCB-126 concentrations were significantly higher in nonsmokers than smokers, 26 versus 13ng/kg. Age, BMI, and local fish consumption were significant predictors of the TEQ associated with serum PCB-126 and PCB-169 concentrations in all subjects, explaining 32% of the variance in the data. Working at the pulp and paper mill and smoking were not associated with the TEQ. In all subjects, PCDDs accounted for 63% of the TEQ, PCDFs for 21%, and PCB-126 and PCB-169 for 15% when calculated according to the Safe technique. When calculated using the WHO procedure, PCDDs, PCDFs, and PCB-126 and PCB-169 contributed 66, 24, and 10% to the TEQ. The authors conclude that PCB-126 and PCB-169 made a significant contribution to the serum TEQ, but serum PCDD concentrations made the largest contribution. [Description provided by NIOSH]
• Subjects:
  Chemistry Diet Occupational Exposure Occupational Health Paper Polychlorinated Biphenyls Safety Smokers Tobacco Products
• Keywords:
  Blood-serum Chemical-structure Chlorinated-dioxins Cigarette-smoking Dietary-effects NIOSH-Author Occupational-exposure Paper-mills Polychlorinated-biphenyls Pulp-industry
• ISSN:
  0045-6535
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  35
• Issue:
  3
• NIOSHTIC Number:
  nn:00238365
• Citation:
  Chemosphere 1997 Aug; 35(3):503-511
• CAS Registry Number:
  3,3′,4,4′,5,5′-Hexachlorobiphenyl (CAS RN 32774-16-6) ; PCB 126 (CAS RN 57465-28-8) ; PCB 77 (CAS RN 32598-13-3)
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  True
• Source Full Name:
  Chemosphere
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8fff7bce99ea7af44f62903a8dd045b7103e4e648248ac396744d8dd8d0d722d668cccf02bd2a6b7cb4451f26ee736bdd1c9b2acde35dc36a7a3c4b57f82790d
• Download URL:
  https://stacks.cdc.gov/view/cdc/197919/cdc_197919_DS1.pdf
• File Type:
  [PDF - 417.79 KB ]