Methodologic Issues in the Use of Biologic Markers in Epidemiologic Research

Details

• Personal Author:
  Schulte, Paul A.
• Description:
  Several methodology issues concerned with the use of biologic markers for epidemiological research studies were discussed in this review. The impact biologic markers have had on epidemiologic research includes the ability to quantify indicators of dose, early effects, predisposition, or confounding which can supplement or replace the nominal and ordinal categories. Biologic markers allow for the resolution of more detail in exposure disease associations. Sometimes biologic markers have caused a change to be made in the unit of analysis from the whole person to the cellular or molecular level. Even though the development and use of biologic markers has increased rapidly, the validity and meaning of many of the markers remain to be established. When analyzing biologic markers, the author urges that great care be taken not to be deceived by the extensive variation in biochemical individuality. Specific concerns for case control, cohort and intervention studies were noted. Ethical issues were considered as they relate to the design and conduct of studies, the interpretation, communication and use of study results, and legal issues. [Description provided by NIOSH]
• Subjects:
  Biochemistry Epidemiology Occupational Health Risk Assessment Risk Factors Safety
• Keywords:
  Biochemical-indicators Biological-monitoring Genotoxic-effects NIOSH-Author Occupational-medicine Risk-analysis Risk-factors
• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  126
• Issue:
  6
• NIOSHTIC Number:
  nn:00238261
• Citation:
  Am J Epidemiol 1987 Dec; 126(6):1006-1016
• Contact Point Address:
  Dr. Paul A. Schulte, National Institute for Occupational Safety and Health, R-13, 4676 Columbia Parkway, Cincinnati, OH 45226
• Federal Fiscal Year:
  1988
• Peer Reviewed:
  True
• Source Full Name:
  American Journal of Epidemiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3977a8875edb03015192a6e44aedd5fa4706812de50cd21bd3bf841e1318c8b0fe7a546d35ab83bd2efd46e6a5829584baa4e70d02edc90ac120109ca97fb9b2
• Download URL:
  https://stacks.cdc.gov/view/cdc/197915/cdc_197915_DS1.pdf
• File Type:
  [PDF - 889.26 KB ]