Interactions of Radiofrequency Radiation on 2-Methoxyethanol Teratogenicity in Rats

Details

• Personal Author:
  Conover, David L. ; Edwards RM ; Nelson BK ; Shaw, Peter B. ; Snyder DL
• Description:
  The interactive effects of radiofrequency (RF) radiation and 2- methoxyethanol (109864) (2-ME) exposure were observed in rats. Mated female CD-Sprague-Dawley-rats were exposed to RF radiation at a frequency of 10 megahertz (MHz) for up to 30 minutes and gavaged with 2-ME at concentrations ranging from 0 to 140mg/kg on gestational day 13. On day 20, the dams were killed and the fetuses were removed and analyzed for external and skeletal malformations. Dose related developmental toxicity was seen for 2-ME, either with or without RF radiation. The dose effect curve of 2-ME was altered by concurrent RF radiation exposure. The authors conclude that, when developing exposure guidelines and intervention strategies, the potential combined effects of exposure should be included in the assessments. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Laboratories Occupational Health Radiation Safety Urogenital System
• Keywords:
  Author Keywords: 2-methoxyethanol Developmental Toxicology Dose-response Ethylene Glycol Monomethyl Ether Ethylenic-alcohols Laboratory-animals Methyl Cellosolve NIOSH-Author Nonionizing Radiation Pregnancy Prenatal-exposure Radiation-exposure Radiofrequency Radiation Reproductive-effects Teratology Toxic-effects

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• ISSN:
  0260-437X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  31-39
• Volume:
  17
• Issue:
  1
• NIOSHTIC Number:
  nn:00236153
• Citation:
  J Appl Toxicol 1997 Jan; 17(1):31-39
• Contact Point Address:
  B. K. Nelson, Division of Biomedical and Behavioral Science, NIOSH C-24, Cincinnati, OH 45226, USA
• CAS Registry Number:
  2-Methoxyethanol (CAS RN 109-86-4)
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Applied Toxicology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:1fb515ee1c4c364a921591b7b9fd3e7744a57bccf09a4d5d5fb564dd1599040a662e872c188dd1efb65d255305aeafc7306f04119c3e82ebbf9d5b6f8d17b0c8
• Download URL:
  https://stacks.cdc.gov/view/cdc/197817/cdc_197817_DS1.pdf
• File Type:
  [PDF - 218.41 KB ]