Review of Experimental Male-Mediated Behavioral and Neurochemical Disorders

Details

• Personal Author:
  Moorman WJ ; Nelson BK ; Schrader, Steven M.
• Description:
  The effects of paternal exposure to exogenous agents on offspring behavior or neurochemical alterations in experimental animals were reviewed. The agents reviewed in this report included age, alcohols, cyclophosphamide (50180), ethylene-dibromide (106934), lead (7439921), opiates, cocaine (50362), ethyl-methanesulfonate (62500), mitomycin-C (50077), and procarbazine (671169). Most of the studies of ethyl-alcohol (64175) indicated that paternal exposure produced hyperactivity in the offspring. Several studies have implicated exposure to cyclophosphamide with neurobehavioral deficits in children. Studies with ethylene-dibromide were suggestive of effects in offspring following paternal exposures, but there was only one laboratory which had investigated this finding. The authors suggest that additional replicatable studies be performed. Lead induced changes in early gene expression in early embryos, as well as alterations in hippocampal development of late fetal and early neonatal rats have been reported. Water maze performance of mice was adversely affected by the paternal exposures to opiates. Cocaine exposure to adult male Long-Evans-rats produced offspring with hyperactivity and a decreased capacity for avoidance learning. [Description provided by NIOSH]
• Subjects:
  Laboratories Lead Lead Poisoning Nervous System Nervous System Diseases Occupational Health Safety Urogenital Diseases Urogenital System
• Keywords:
  Developmental-disorders Laboratory-animals Lead-poisoning Nervous-system-disorders Neuropathology Prenatal-exposure Reproductive-hazards
• ISSN:
  0892-0362
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  6
• NIOSHTIC Number:
  nn:00234982
• Citation:
  Neurotoxicol Teratol 1996 Nov; 18(6):611-616
• CAS Registry Number:
  1,2-Dibromoethane (CAS RN 106-93-4) ; Cocaine (CAS RN 50-36-2) ; Cyclophosphamide (CAS RN 50-18-0) ; Ethanol (CAS RN 64-17-5) ; Ethyl methanesulfonate (CAS RN 62-50-0) ; Lead (CAS RN 7439-92-1) ; Mitomycin C (CAS RN 50-07-7) ; Procarbazine (CAS RN 671-16-9)
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  True
• Source Full Name:
  Neurotoxicology and Teratology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:347b13b4ccb9378d181c2d76e21b5e1e2f518e25339e99e50c1d79ca6afac34997d78e3c03b72585549e2f6538cc154c91527abb8fef01256cd7703e84205e8d
• Download URL:
  https://stacks.cdc.gov/view/cdc/197743/cdc_197743_DS1.pdf
• File Type:
  [PDF - 911.49 KB ]