Quantitative Measure of Genetic Differences in Susceptibility to Noise-Induced Hearing Loss in Two Strains of Mice

Details

• Personal Author:
  Cheever ML ; Davis, Rickie R. ; Erway LC ; Kreig EF
• Description:
  The CBA/CaJ (CB) and C57BL/6J (B6) inbred strains of mice were exposed for 1 h to noise intensities between 98 and 119 dB SPL. Previous studies indicated that the B6 mice exhibited permanent threshold shifts (PTS) after 1 h exposure to 110 dB, whereas the CB mice did not exhibit any PTS. These differences in susceptibility to noise-induced hearing loss (NIHL) appear to be due to a gene for age-related hearing loss (AHL). The current study was designed to determine dose-response curves for NIHL over the ranges of intensities of noise that would characterize the B6 and CB inbred strains of mice. Because of the considerable differences in sensitivity to NIHL, the noise exposures for the two strains overlapped only at 110 and 113 dB. Nevertheless, the two strains exhibited two different dose-response curves, offset and with different slopes. We postulate that the B6 strain of mice exhibits a more linear increase for PTS from 98-113 dB, consistent with incremental effects on some metabolic physiological mechanism(s); the abrupt transition in NIHL between 113 and 116 dB for the CB mice is consistent with an ototraumatic structural injury. [Description provided by NIOSH]
• Subjects:
  Age Factors Hearing Loss Hearing Loss, Noise-Induced Laboratories Noise Noise, Occupational Occupational Health Personal Protective Equipment Safety Workplace
• Keywords:
  Age-factors Hearing-disorders Hearing-loss Hearing-protection Laboratory-animals Laboratory-testing Noise-analysis Noise-exposure Noise-induced-hearing-loss Noise-protection Statistical-analysis Workplace-studies

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• ISSN:
  0378-5955
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Florida ; Ohio ; OSHA Region 4 ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DBBS - Division of Biomedical and Behavioral Sciences
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  9-15
• Volume:
  134
• Issue:
  1
• NIOSHTIC Number:
  nn:20027665
• Citation:
  Hear Res 1999 Aug; 134(1-2):9-15
• Federal Fiscal Year:
  1999
• Peer Reviewed:
  True
• Source Full Name:
  Hearing Research
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:dcd64f8d4a09782a36f67617acf02058a7850fc156e8e4ef7ba799067edb25bb4c088a7acba7deb67fef7bbf859b53c7704bce79fb027a7f5b6f5b1f5584f8a8
• Download URL:
  https://stacks.cdc.gov/view/cdc/197615/cdc_197615_DS1.pdf
• File Type:
  [PDF - 287.24 KB ]