Workplace Safety and Food Ingredients: The Example of Butter Flavoring

Details

• Personal Author:
  Battelli L ; Castranova, Vincent ; Friend S ; Goldsmith W ; Hubbs A ; Jones, William G. ; Kreiss, Kathleen ; Kullman, Greg J. ; Mercer RR ; Porter, Dale ; Schwegler-Berry D
• Description:
  Chemical toxicity is often dependent upon the concentration and route of exposure. Therefore, compounds which are safe when consumed at low concentrations are not necessarily safe at higher concentrations and/or by a different route, such as inhalation. Due to a high prevalence of lung disease in microwave popcorn manufacturing workers, we investigated the potential for butter flavoring vapors to damage the epithelial lining of nasal passages and pulmonary airways. Inhaling a butter flavoring vapor mixture containing 203-371 ppm of the diacetyl component caused degeneration and death of rat nasal and airway epithelial cells. These are concentrations workers could encounter for short periods. We are actively investigating the specific agent(s) in butter flavoring which can injure respiratory epithelium. [Description provided by NIOSH]
• Subjects:
  Chemistry Environmental Monitoring Food Additives Food Handling Food Industry Lung Lung Diseases Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Chemical-analysis Exposure-assessment Exposure-levels Food-additives Food-processing Lung-disease Lung-disorders Lung-irritants Pulmonary-system-disorders Respiratory-system-disorders
• Publisher:
  American Chemical Society
• Document Type:
  Text
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  District of Columbia ; Massachusetts ; OSHA Region 1 ; OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division ; DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• NIOSHTIC Number:
  nn:20027663
• Citation:
  Proceedings of the 224th Meeting of the American Chemical Society, Boston, MA; August 18-22, 2002. Washington, DC: American Chemical Society, 2002 Aug; 1:148
• Contact Point Address:
  National Institute for Occupational Safety and Health, 1095 Willowdale RD. M/S 2015, Morgantown, WV 26505
• Email:
  afh0@cdc.gov
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Work Environment and Workforce: Mixed Exposures
• Peer Reviewed:
  False
• Part Number:
  1
• Source Full Name:
  Proceedings of the 224th Meeting of the American Chemical Society, Boston, MA; August 18-22, 2002
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ba23639901606851ef0d46a6c30b600a7de17a2af44a4e014730fc7310158129029c717c5704577eab5638c36a862fb302a65061b2d0021e338568ca2c6ac814
• Download URL:
  https://stacks.cdc.gov/view/cdc/197613/cdc_197613_DS1.pdf
• File Type:
  [PDF - 551.77 KB ]