A 13-C CP/MAS and 31-P NMR Study of the Interactions of Dipalmitoylphosphatidylcholine with Respirable Silica and Kaolin

Details

• Personal Author:
  Harrison JC ; Murray DK ; Wallace WE
• Description:
  The interaction of silica and kaolin with dipalmitoylphosphatidylcholine (DPPC) has been studied using (13)C and (31)P solid state nuclear magnetic resonance spectroscopy. These studies explore the molecular interactions of these respirable dusts with a model lung surfactant species to characterize silica toxicity in mixed systems. The choline head group of DPPC was found to remain mobile when adsorbed on kaolin, in contrast to an immobile head group on silica. Further, glycerol carbon intensities were greatly diminished relative to that of choline carbons, a result attributed to broadening effects. These preliminary findings suggest that silica toxicity may not be related to choline mobility as previously noted [J. Colloid Interface Sci. 172 (1995) 536-538]. [Description provided by NIOSH]
• Subjects:
  Aluminum Silicates Dust Lung Occupational Health Respiratory System Safety Silicon Dioxide Surface-Active Agents
• Keywords:
  Author Keywords: DPPC Dipalmitoylphosphatidylcholine Dust-particles Dusts Kaolin Lung Surfactant Models NMR Respirable-dust Respirable Dust Silanol Silica Silica-dusts Silicates Silicosis Surfactants

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• ISSN:
  0021-9797
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  166-170
• Volume:
  288
• Issue:
  1
• NIOSHTIC Number:
  nn:20027436
• Citation:
  J Colloid and Interface Sci 2005 Aug; 288(1):166-170
• Contact Point Address:
  National Institute for Occupational Health and Safety, 1095 Willowdale Road, M/S 3030, Morgantown, WV 26505, USA
• Email:
  dmurray@cdc.gov
• CAS Registry Number:
  Kaolin (CAS RN 1332-58-7)
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Peer Reviewed:
  True
• Source Full Name:
  Journal of Colloid and Interface Science
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:233785ca7d61142a21f4dcbf4d48128229afbb46bf8f48607be603b3a482010c6103cb0946b1a466a2a97d507e134dfcdc5b6f325d7a8ed0e3904413790155bb
• Download URL:
  https://stacks.cdc.gov/view/cdc/197576/cdc_197576_DS1.pdf
• File Type:
  [PDF - 679.50 KB ]