Interactions of Mercury, Selenium, Tellurium, and Arsenic

Details

• Personal Author:
  Groth DH ; Mackay GR ; Stettler, Lloyd E.
• Description:
  The purpose of this paper is to present some of the published data and some unpublished findings on the biological interactions of selenium (Se) with arsenic (As), mercury (Hg) and tellurium (Te). From the point of view of classical toxicology the experimental data arising from the studies of these interactions appear contradictory and confusing. In particular is the observation that the combined administration of two highly toxic salts, mercuric chloride (HgC12) and sodium selenite (Na2Se03) results in a reduction in toxicity of both chemicals. Not only is that unusual, but at the same time the tissue concentrations of these two elements are not decreased as one might expect, but are greatly increased above the levels achieved by injecting either one alone. Combined with this are the many variables that influence the toxicity of chemicals, namely, (1) nutrition, (2) animal species, (3) route of administration, (4) dose, (5) duration of exposure, (6) sequence of administration, (7) interval between injections, and (8) the chemical compound in which the element occurs. Not all of these variables will be covered in this brief article, but the data will be presented in categories of the effect of each element on the other element's toxicity, tissue concentration and metabolism. [Description provided by NIOSH]
• Subjects:
  Arsenic Biochemistry Carcinogens Chemistry Environmental Monitoring Inorganic Chemicals Laboratories Mercury Metals Metals, Heavy Occupational Health Poisoning Safety

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• Keywords:
  Arsenic-compounds Arsenic-poisoning Biochemical-analysis Biochemical-tests Carcinogenesis Chemical-properties Data-processing Exposure-assessment Heavy-metal-poisoning Heavy-metals Laboratory-animals Mercury-compounds Mercury-poisoning Metallic-poisons Organo-metallic-compounds Physical-properties Selenium-compounds Statistical-analysis Tellurium-compounds Tissue-culture Tissue-disorders

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• Publisher:
  Industrial Health Foundation
• Document Type:
  Text
• Genre:
  Proceedings
• Place as Subject:
  Indiana ; Ohio ; OSHA Region 3 ; OSHA Region 5 ; Pennsylvania
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DLCD - Division of Laboratories and Criteria Development
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  85-103
• NIOSHTIC Number:
  nn:20027219
• Citation:
  Proceedings of the Symposium on Selenium-Tellurium in the Environment, Notre Dame, IN, May 11-13, 1976. Pittsburgh, PA: Industrial Health Foundation, Inc., 1976 May; :85-103
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2) ; Mercury (CAS RN 7439-97-6) ; Selenium (CAS RN 7782-49-2) ; Tellurium (CAS RN 13494-80-9)
• Federal Fiscal Year:
  1976
• Peer Reviewed:
  False
• Source Full Name:
  Effects and Dose-Response Relationships of Toxic Metals, Notre Dame, IN, May 11-13, 1976
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ddbbb022783e65042879efa595adae0dbe34c35a4d322aff32f3f8dc5256ffd66dff552cb61112f83ede2224dff4326bb37e7d29be59feaa90bfe9672512e5f3
• Download URL:
  https://stacks.cdc.gov/view/cdc/197510/cdc_197510_DS1.pdf
• File Type:
  [PDF - 3.53 MB ]