Lack of Association Between Antioxidant Gene Polymorphisms and Progressive Massive Fibrosis in Coal Miners

Details

• Personal Author:
  Fluharty K ; Johnson VJ ; Kashon ML ; Luster MI ; Vallyathan V ; Yucesoy, Berran
• Description:
  Oxidative stress plays a major role in the pathogenesis of interstitial lung diseases. The antioxidant enzymes glutathione S-transferases (GST) and manganese superoxide dismutase (MnSOD) are important components of lung defence against oxidative stress, and polymorphisms in the genes which regulate their expression may represent important disease modifiers. A matched case-control study was conducted to determine the influence of the GSTP1, GSTT1 and MnSOD polymorphisms on susceptibility to progressive massive fibrosis (PMF). Seven hundred ex-coal miners were included in the study; 350 were classified as PMF cases while 350 with a similar underground mining tenure but no clinical or histological evidence of lung disease served as controls. Genotype analysis was performed on genomic DNA, using a 5' nuclease PCR assay. None of the individual investigated polymorphisms and two-way gene-gene interactions had a statistically significant association with PMF. The results of this study suggest that polymorphic genotypes within the GST gene cluster and MnSOD do not affect individual susceptibility to PMF. [Description provided by NIOSH]
• Subjects:
  Antioxidants Coal Coal Mining Dust Environmental Exposure Fibrosis Genetics Lung Lung Diseases Mining Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Coal-miners Diseases Dust-exposure Environmental-exposure Fibrogenesis Fibrogenicity Genes Genetic-factors Lung-disease Lung-tissue Mineral-dusts Pathogenesis Pneumoconiosis Pulmonary-system-disorders Respiratory-system-disorders

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• ISSN:
  0040-6376
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  492-495
• Volume:
  60
• Issue:
  6
• NIOSHTIC Number:
  nn:20027013
• Citation:
  Thorax 2005 Jun; 60(6):492-495
• Contact Point Address:
  B. Yucesoy, PhD, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, West Virginia 26505-2888
• Email:
  yab7@cdc.gov
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  Thorax
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:0ab3443b787b784dc1296478d59aad319d57872d0fb089ce28e8e9f27ad41851fe4ea244301db23ecbc62301a10c628b0f617604514a1ac080126c0002380fc9
• Download URL:
  https://stacks.cdc.gov/view/cdc/197433/cdc_197433_DS1.pdf
• File Type:
  [PDF - 69.31 KB ]