Physicochemical Determinants of Linear Alkylbenzene Sulfonate (LAS) Disposition in Skin Exposed to Aqueous Cutting Fluid Mixtures

Details

• Personal Author:
  Barlow BM ; Baynes RE ; Brooks JD ; Riviere JE
• Description:
  Linear alkylbenzene sulfonate (LAS) is added to cutting fluid formulations to enhance the performance of metal machining operations, but this surfactant can cause contact dermatitis in workers involved in these operations. The purpose of this study was to determine how cutting fluid additives influence dermal disposition of 14C-LAS in mineral oil- or polyethylene glycol 200 (PEG)-based mixtures when topically applied to silastic membranes and porcine skin in an in vitro flow-through diffusion cell system. 14C-LAS mixtures were formulated with three commonly used cutting fluid additives; 0 or 2% triazine (TRI), 0 or 5% triethanolamine (TEA), and 0 or 5% sulfurized ricinoleic acid (SRA). LAS absorption was limited to less than a 0.5% dose and the additives in various combinations influenced the physicochemical characteristics of the dosing mixture. LAS was more likely to partition into the stratum corneum (SC) in mineral oil mixtures, and LAS absorption was significantly greater in the complete mixture. TRI enhanced LAS transport, and the presence of SRA decreased LAS critical micelle concentration (CMC) which reduced LAS monomers available for transport. TEA increased mixture viscosity, and this may have negated the apparent enhancing properties of TRI in several mixtures. In summary, physicochemical interactions in these mixtures influenced availability of LAS for absorption and distribution in skin, and could ultimately influence toxicological responses in skin. [Description provided by NIOSH]
• Subjects:
  Dermatitis Irritants Metals Metal Workers Occupational Exposure Occupational Health Particulate Matter Safety Skin Skin Absorption Skin Diseases

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• Keywords:
  Author Keywords: Cutting Fluids Biocides Cutting-oils Dermatosis Detergent-enzymes In-vitro-studies LAS Metal-industry Metalworking Metalworking-fluids Metalworking-industry Mixtures Occupational-dermatitis Occupational-exposure Oil-mists Physicochemical Interactions Skin-absorption Skin-exposure Skin-irritants Skin-sensitivity

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• ISSN:
  0748-2337
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  North Carolina ; OSHA Region 4
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  237-248
• Volume:
  18
• Issue:
  5
• NIOSHTIC Number:
  nn:20026945
• Citation:
  Toxicol Ind Health 2002 Jun; 18(5):237-248
• Contact Point Address:
  Center for Chemical Toxicology Research and Pharmacokinetics (CCTRP), College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606
• CAS Registry Number:
  Triethanolamine (CAS RN 102-71-6)
• Federal Fiscal Year:
  2002
• NORA Priority Area:
  Disease and Injury: Allergic and Irritant Dermatitis
• Performing Organization:
  North Carolina State University, Raleigh, North Carolina
• Peer Reviewed:
  True
• Start Date:
  20000801
• Source Full Name:
  Toxicology and Industrial Health
• End Date:
  20150731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:ce1ac6276b40d6d040a1553f9dbc1bdce4a417c352f1652257bc51c4eca201e474d73e37e4683e64d0a82ae634045ee240b6d9fee67ba8b2df33f9f4b5c0e98d
• Download URL:
  https://stacks.cdc.gov/view/cdc/197412/cdc_197412_DS1.pdf
• File Type:
  [PDF - 501.73 KB ]