Relation of Aortic Valve Sclerosis to Risk of Coronary Heart Disease in African-Americans

Details

• Personal Author:
  Andrew, Michael E. ; Arnett DK ; Clark BL ; Fox ER ; Garrison RJ ; Han H ; Jones DW ; Samdarshi T ; Taylor HA
• Description:
  To assess the relation between aortic valve sclerosis (AVS) and subsequent occurrence of coronary heart disease (CHD) events, we analyzed echocardiographic data obtained from 2,279 middle-aged African-Americans enrolled in the Jackson Mississippi Atherosclerosis Risk in Communities study cohort who were free of known CHD at the time of the examination. Cox regression analyses demonstrated a hazard ratio of 3.8 for incident first myocardial infarction or fatal CHD after adjusted for multiple risk factors, including markers of inflammation. An amplification of CHD risk in the AVS subgroup with high levels of serum inflammatory markers (the highest quartile of fibrinogen and von Willebrand Factor levels) demonstrated greater than fivefold higher risk of CHD associated with AVS than risk in the lowest quartile. [Description provided by NIOSH]
• Subjects:
  Cardiovascular Diseases Cardiovascular System Epidemiology Occupational Health Race Factors Safety
• Keywords:
  Cardiac-function Cardiology Cardiovascular-disease Cardiovascular-system-disease Cardiovascular-system-disorders Heart Humans Racial-factors Statistical-analysis
• ISSN:
  0002-9149
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  Mississippi ; OSHA Region 3 ; OSHA Region 4 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  401-404
• Volume:
  95
• Issue:
  3
• NIOSHTIC Number:
  nn:20026080
• Citation:
  Am J Cardiol 2005 Feb; 95(3):401-404
• Contact Point Address:
  Dr. H. A. Taylor, Jackson Heart Study, 350 West Woodrow Wilson, Suite 701, Jackson, Mississippi 39213
• Federal Fiscal Year:
  2005
• Peer Reviewed:
  True
• Source Full Name:
  The American Journal of Cardiology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8af2223ae8aa40cb47f534ec5f10eb848ba96e13148e93fa3c2ba9d8408eaf651c77fe36a81e7cf313ea5f533509ce64ef360140cbb82c5f5cbfc9f0c0e7ccfc
• Download URL:
  https://stacks.cdc.gov/view/cdc/197184/cdc_197184_DS1.pdf
• File Type:
  [PDF - 83.52 KB ]