Effect of Fume Exposure on FEV1 in Early COPD

Details

• Personal Author:
  Connett JE ; Crawford L ; Harber P ; Hnizdo, Eva ; Simmons M ; Tashkin D
• Description:
  Occupational exposures, in addition to smoking, may contribute to development and progression of COPD. SUBJECTS: Data are for 5734 subjects in the Lung Health Study (LHS), a study of smoking cessation interventions for persons with early COPD (defined as FEV1/FVC ratio < 0.70 and FEV1 55% - 90% predicted). Each had baseline and up to 5 annual follow-up spirometry tests. METHODS: FEV1% predicted post-bronchodilator at each follow-up year was modeled as determined by both baseline characteristics and time-dependent variables using a repeated-measures general linear model with first-order autoregression. Baseline characteristics included age, airway responsiveness by methacholine challenge, baseline FEVI, and self-reported dust exposure, fume exposure, and mask use. Time-dependent variables' included smoking (smoking status, cigarettes/day, or smoking intensity as a categorical variable) and self-reported dust exposure, fume exposure, and mask use. RESULTS: Exposure to "fume" (both as a baseline characteristic and as a time-dependent characteristic) showed relationships to FEV1 in many models. Significant results were found in men, but not in women. Subjects reporting fume exposure at baseline had 0.44% lower FEV1% predicted than those not reporting (p < 0.06), and fume exposure at any follow-up year was associated with a 0.21% lower FEV1% predicted (p < 0.05) when adjusted for age, baseline FEV1% predicted, smoking status, and baseline cigarettes! day. No significant effects of dust exposure or mask use were observed. CONCLUSIONS: There is an indication that self-reported fume exposure adversely affects FEV1 in persons with early COPD. The effect may be additive to that of smoking and be present even if smoking ceases. Description provided by NIOSH
• Subjects:
  • Epidemiology
  • Lung
  • Lung Diseases
  • Occupational Health
  • Respiratory Function Tests
  • Respiratory System
  • Respiratory Tract Diseases
  • Safety
  • Smoke
  • Smokers
  More +
• Keywords:
  • Pulmonary-function
  • Pulmonary-function-tests
  • Respiratory-function-tests
  • Epidemiology
  • Statistical-analysis
  • Humans
  • Lung-function
  • Pulmonary-system-disorders
  • Pulmonary-disorders
  • Respiratory-system-disorders
  More +
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; Minnesota ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  169
• Issue:
  7
• NIOSHTIC Number:
  nn:20026044
• Citation:
  Am J Respir Crit Care Med 2004 Apr; 169(7)(Abstracts):A46
• Email:
  pharber@mednet.ucla.edu
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Performing Organization:
  University of California, School of Public Health, Los Angeles, California
• Peer Reviewed:
  False
• Start Date:
  19990701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Abstracts
• End Date:
  20040630
• Download URL:
  https://stacks.cdc.gov/view/cdc/197166/cdc_197166_DS1.pdf
• File Type:
  [PDF - 402.22 KB]
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c656a44c8ff82325c8168d5b0f440d484bd7d464dc563628d0df55c682d8a4e35ea471d7ae91038d9783c834de815f3bd3bdda3a926568c3de49cd480ffcf4af