Effect of Fume Exposure on FEV1 in Early COPD

Details

• Personal Author:
  Connett JE ; Crawford L ; Harber P ; Hnizdo, Eva ; Simmons M ; Tashkin D
• Description:
  Occupational exposures, in addition to smoking, may contribute to development and progression of COPD. SUBJECTS: Data are for 5734 subjects in the Lung Health Study (LHS), a study of smoking cessation interventions for persons with early COPD (defined as FEV1/FVC ratio < 0.70 and FEV1 55% - 90% predicted). Each had baseline and up to 5 annual follow-up spirometry tests. METHODS: FEV1% predicted post-bronchodilator at each follow-up year was modeled as determined by both baseline characteristics and time-dependent variables using a repeated-measures general linear model with first-order autoregression. Baseline characteristics included age, airway responsiveness by methacholine challenge, baseline FEVI, and self-reported dust exposure, fume exposure, and mask use. Time-dependent variables' included smoking (smoking status, cigarettes/day, or smoking intensity as a categorical variable) and self-reported dust exposure, fume exposure, and mask use. RESULTS: Exposure to "fume" (both as a baseline characteristic and as a time-dependent characteristic) showed relationships to FEV1 in many models. Significant results were found in men, but not in women. Subjects reporting fume exposure at baseline had 0.44% lower FEV1% predicted than those not reporting (p < 0.06), and fume exposure at any follow-up year was associated with a 0.21% lower FEV1% predicted (p < 0.05) when adjusted for age, baseline FEV1% predicted, smoking status, and baseline cigarettes! day. No significant effects of dust exposure or mask use were observed. CONCLUSIONS: There is an indication that self-reported fume exposure adversely affects FEV1 in persons with early COPD. The effect may be additive to that of smoking and be present even if smoking ceases. [Description provided by NIOSH]
• Subjects:
  Epidemiology Lung Lung Diseases Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety Smoke Smokers Tobacco Products

  More +
• Keywords:
  Cigarette-smoking Humans Lung-function Pulmonary-disorders Pulmonary-function Pulmonary-function-tests Pulmonary-system-disorders Respiratory-function-tests Respiratory-system-disorders Smoking Spirometry Statistical-analysis Surveillance Tobacco-smoke

  More +
• ISSN:
  1073-449X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary
• Place as Subject:
  California ; Minnesota ; OSHA Region 3 ; OSHA Region 5 ; OSHA Region 9 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  169
• Issue:
  7
• NIOSHTIC Number:
  nn:20026044
• Citation:
  Am J Respir Crit Care Med 2004 Apr; 169(7)(Abstracts):A46
• Email:
  pharber@mednet.ucla.edu
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Disease and Injury: Asthma and Chronic Obstructive Pulmonary Disease
• Performing Organization:
  University of California, School of Public Health, Los Angeles, California
• Peer Reviewed:
  False
• Start Date:
  19990701
• Source Full Name:
  American Journal of Respiratory and Critical Care Medicine
• Supplement:
  Abstracts
• End Date:
  20040630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:c656a44c8ff82325c8168d5b0f440d484bd7d464dc563628d0df55c682d8a4e35ea471d7ae91038d9783c834de815f3bd3bdda3a926568c3de49cd480ffcf4af
• Download URL:
  https://stacks.cdc.gov/view/cdc/197166/cdc_197166_DS1.pdf
• File Type:
  [PDF - 402.22 KB ]