Mortality Patterns in Indiana Workers Exposed to Polychlorinated Biphenyls (PCBs)

Details

• Personal Author:
  Davis-King K ; Hein, Misty J. ; Laber P ; Nilsen N ; Prince, Mary M. ; Ruder, Avima M. ; Waters MA ; Whelan, Elizabeth A.
• Description:
  Background: Mortality was updated through 1998 for 3,588 workers exposed to polychlorinated biphenyls (PCBs) between 1957 and 1986 at a capacitor manufacturing plant, to evaluate excess melanoma and brain cancer, originally seen in this cohort, and rectal, liver, biliary tract, and gall bladder cancer, and non-Hodgkins lymphoma, observed in other PCB studies. Methods: Standardized mortality ratios (SMR) and 95% confidence intervals (CI) used Indiana state (shown) and U. S. rates. A new job-exposure matrix calculated estimated cumulative exposure. Results: Overall mortality was reduced (547 deaths, SMR 0.81, CI 0.75, 0.88). Melanoma was significantly elevated (9 deaths, SMR 2.43, CI 1.11,4.60); brain cancer (12 deaths, SMR 1.91, CI 0.98, 3.33) and non-Hodgkins lymphoma (9 deaths, SMR 1.23, CI 0.56, 2.33) were elevated. Other cancers of a priori interest were not in excess. When the cohort was stratified by quartiles of estimated cumulative exposure, melanoma was in excess in the lowest quartile (4 deaths, SMR 4.09, CI 1.12, 10.5), with a trend (p = 0.014) of decreasing SMR with increasing exposure. Brain cancer was in excess in the highest quartile (5 deaths, SMR 3.55, CI US, 8.28) but there was no dose response trend. Among 2,789 individuals who worked at least 90 days, both melanoma (8 deaths, SMR 2.66, CI 1.15,24) and brain cancer (II deaths, SMR 2.12, CI 1.06, 80) were in excess. Conclusion: These findings reinforce those of the original study. For both melanoma and brain cancer, mortality and estimated cumulative exposure do not fulfill dose-response relationships. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Epidemiology Liver Mortality Neoplasms Nervous System Nervous System Diseases Nervous System Disorders Occupational Health Polychlorinated Biphenyls Safety Skin Skin Diseases Urogenital Diseases Urogenital System

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• Keywords:
  Bladder-cancer Bladder-disease Bladder-disorders Brain-tumors Central-nervous-system-disorders Gastrointestinal-system Gastrointestinal-system-disorders Liver-cancer Liver-disorders Liver-tumors Mortality-data Mortality-rates Mortality-surveys Polychlorinated-biphenyls Skin-cancer Skin-diseases Skin-disorders Statistical-analysis

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• ISSN:
  0002-9262
• Document Type:
  Text
• Genre:
  Abstract or Summary
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DSHEFS - Division of Surveillance, Hazard Evaluations, and Field Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  159
• Issue:
  11
• NIOSHTIC Number:
  nn:20026029
• Citation:
  Am J Epidemiol 2004 Jun; 159(11)(Suppl):S20
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  False
• Source Full Name:
  American Journal of Epidemiology. Society for Epidemiologic Research (SER). Abstracts of the 37th Annual Meeting, Salt Lake City, Utah, June 15-18, 2004
• Supplement:
  Suppl
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:4399e135bf0e504d523b4abaefa2d7fb388eaf53b683e9781f3b5e73296a930b28d729d2cc50966e58b07b31e2f7a4b8a554be7bb9f178bae700fd2888779cbd
• Download URL:
  https://stacks.cdc.gov/view/cdc/197155/cdc_197155_DS1.pdf
• File Type:
  [PDF - 322.52 KB ]