Biocidal Activity of Formaldehyde and Nonformaldehyde Biocides Toward Mycobacterium immunogenum and Pseudomonas fluorescens in Pure and Mixed Suspensions in Synthetic Metalworking Fluid and Saline

Details

• Personal Author:
  Khan IUH ; Selvaraju SB ; Yadav JS
• Description:
  The microbicidal activity of four different biocides was studied in synthetic metalworking fluid (MWF) against Mycobacterium immunogenum, a suspected causative agent for hypersensitivity pneumonitis, and Pseudomonas fluorescens, a representative for the predominant gram-negative bacterial contaminants of MWF. The results indicated that M. immunogenum is more resistant than P. fluorescens to the tested formaldehyde-releasing biocides (Grotan and Bioban), isothiazolone (Kathon), and phenolic biocide (Preventol). Kathon was effective against mycobacteria at lower concentrations than the other three test biocides in MWF. In general, there was a marked increase in biocidal resistance of both the test organisms when present in MWF matrix compared to saline. Increased resistance of the two test organisms to biocides was observed when they were in a mixed suspension (1:1 ratio). The results indicate the protective effect of the MWF matrix against the action of commonly used biocides on the MWF-colonizing microbial species of occupational health significance, including mycobacteria. [Description provided by NIOSH]
• Subjects:
  Bacterial Infections Metals Metal Workers Microbiology Occupational Health Respiratory Tract Diseases Safety Viral Diseases
• Keywords:
  Bacteria Bacterial-disease Bacterial-infections Metalworking Metalworking-fluids Metalworking-industry Microorganisms Pulmonary-system-disorders Respiratory-system-disorders Viral-diseases Viral-infections

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• ISSN:
  0099-2240
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  71
• Issue:
  1
• NIOSHTIC Number:
  nn:20025937
• Citation:
  Appl Environ Microbiol 2005 Jan; 71(1):542-546
• Contact Point Address:
  Molecular Toxicology Division, Department of Environmental Health, University of Cincinnati Medical Center, Cincinnati, OH 45267-0056
• Email:
  Jagjit.Yadav@uc.edu
• Federal Fiscal Year:
  2005
• NORA Priority Area:
  Research Tools and Approaches: Exposure Assessment Methods
• Performing Organization:
  University of Cincinnati
• Peer Reviewed:
  True
• Start Date:
  20010930
• Source Full Name:
  Applied and Environmental Microbiology
• End Date:
  20170731
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:30e231cb485580902d88ca04a15e47c9d35c88904aa4ae15f6cb732ca71acde0169546fd8367dca49229bbf38d25843b5f5673c90643af2afe7c6e86a8c3e80d
• Download URL:
  https://stacks.cdc.gov/view/cdc/197101/cdc_197101_DS1.pdf
• File Type:
  [PDF - 197.74 KB ]