Preliminary Findings That Kerosene Alters the Distribution of Topically Applied Benzo[a]pyrene in Mice

Details

• Personal Author:
  Hoath S ; LaDow K ; Luse N ; Pickens B ; Pickens W ; Schumann BL ; Talaska G ; Warshawsky D
• Description:
  The dermal route is important in occupational exposure to polycyclic aromatic compounds (PACs), but other organs may be affected. We reported that kerosene-cleaning following treatment with used engine oil increased DNA adducts in the lungs of mice viz. animals treated with used oil alone. To determine the mechanism we topically applied 3H-BAP(100 nmol in 25 microL acetone) and washed half the mice with 25 microL kerosene 1 h after carcinogen application. Groups of four mice were sacrificed from 1 to 72 h after treatment. Lung, liver, and skin were harvested. The fraction of the radiolabel remaining in the skin of animals treated with benzo[a]pyrene (BAP) and washed with kerosene was significantly less than those not washed, beginning at 24 h (p < .05). Fractional distribution to the lungs and livers of these animals became significantly elevated. Kerosene increased transdermal water loss. Kerosene treatment compromises dermal barrier function, enhances carcinogen absorption, and alters organ distribution. [Description provided by NIOSH]
• Subjects:
  Animals Energy Metabolism Hydrocarbons Laboratories Occupational Health Petroleum Polycyclic Aromatic Hydrocarbons Safety Skin
• Keywords:
  Animal-studies Author Keywords: Benzo[a]pyrene Dermal Route Laboratory-animals Metabolic-study Mixtures Organotropism Petroleum-products Polycyclic-aromatic-hydrocarbons Polycyclic-hydrocarbons Skin-exposure

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• ISSN:
  1040-6638
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Ohio ; OSHA Region 5
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  24
• Issue:
  4
• NIOSHTIC Number:
  nn:20025877
• Citation:
  Polycycl Aromat Compd 2004 Aug-Dec; 24(4/5):597-605
• Federal Fiscal Year:
  2004
• NORA Priority Area:
  Research Tools and Approaches: Risk Assessment Methods
• Performing Organization:
  University of Cincinnati, Cincinnati, Ohio
• Peer Reviewed:
  True
• Start Date:
  19990930
• Source Full Name:
  Polycyclic Aromatic Compounds
• End Date:
  20030929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:6d42ba776fe2ca44565b8c2846ee3775b9bfa77081d29a6f0484606abc9237b00e28a16de1119c9b28284709749027949d22c5c32961be0e865bd3e60bad27ae
• Download URL:
  https://stacks.cdc.gov/view/cdc/197072/cdc_197072_DS1.pdf
• File Type:
  [PDF - 787.63 KB ]