Particulates and the Airways: Basic Biological Mechanisms of Pulmonary Pathogenicity

Details

• Personal Author:
  Castranova, Vincent
• Description:
  With strong evidence that materials such as silica and asbestos are associated with irreversible lung disease, efforts have been made to identify abrasive substitute materials for silica and produce various synthetic vitreous fibers as substitutes for asbestos. With the introduction of new materials, questions concerning potential health effects are raised. A clear understanding of the mechanisms by witch certain inhaled particles induce lung damage and subsequent disease is vital to the ability to predict the relative safety of new materials, as well as, to provide appropriate measures for the safe use of old materials currently grouped together as particulates not otherwise classified/regulated. The following is a brief review of mechanisms currently thought to be important in the development and progression of particle-induced lung disease. [Description provided by NIOSH]
• Subjects:
  Asbestos Cytotoxins Dust Inorganic Chemicals Lung Lung Diseases Occupational Health Particulate Matter Respiratory System Respiratory Tract Diseases Safety Silicon Dioxide

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• Keywords:
  Asbestos-dust Asbestos-fibers Cytotoxicity Lung-disease Lung-disorders Lung-function Lung-irritants Particulate-dust Particulate-sampling-methods Pulmonary-function Pulmonary-system-disorders Silica-dusts

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• ISSN:
  1047-322X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  13
• Issue:
  8
• NIOSHTIC Number:
  nn:20025806
• Citation:
  Appl Occup Environ Hyg 1998 Aug; 13(8):613-616
• Contact Point Address:
  Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505
• Federal Fiscal Year:
  1998
• Peer Reviewed:
  True
• Source Full Name:
  Applied Occupational and Environmental Hygiene
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d5b513056858e53a21d302322f9c8e9393b4f6f045073701d47474493cc28ae5822c61712a9add6ddce759a5cc54f38076a6a4c74f02f9dcbb0c163c9ac0a7db
• Download URL:
  https://stacks.cdc.gov/view/cdc/197025/cdc_197025_DS1.pdf
• File Type:
  [PDF - 587.07 KB ]