Folpet Permeation Through Nitrile Gloves

Details

• Personal Author:
  Que Hee SS ; Zainal H
• Description:
  The aim of this study was to investigate whether two different brands of unsupported and unlined nitrile gloves protected against aqueous emulsions of a Folpet wettable powder (50% Folpet) using an ASTM type-I-PTC 600 permeation cell at 30.0 +/- 0.1 degrees C held in a shaking water bath. An analytical method to determine Folpet using the internal standard method was first developed based on gas chromatography-mass spectrometry (GC-MS), and gas chromatography-electron capture detection (GC-ECD). A novel pyrolysis GC-ECD technique that quantified the thermal degradation product phthalimide had pg sensitivity suitable to detect the trace amounts of Folpet that permeated. The on-column conversion was (68.0 +/- 9.5) percent at 170 degrees C over the folpet injected mass range of 3 to 148 pg. The challenge solution in the permeation cell was 1.4 mg/mL aqueous emulsion of Folpet wettable powder, and 2-propanol was the collection solvent. After evaporation of the collection solvent, the time weighted average rate of permeation of Folpet through SafeSkin nitrile (an exams type of glove) after 8 hours was (42.1 +/- 2.9) ng/cm(2)/min compared with (2.04 +/- 0.69) ng/cm(2)/min for the Sol-Vex nitrile (industrial chemical resistant), the latter being about 21 times more protective and also near the limits of detection. The respective values after 4 hours of exposure were (28.4 +/- 1.2) and (0.65 +/- 0.36) ng/cm(2)/min. Diagnostic reflectance infrared minima of both challenge and collection sides of the gloves showed small changes in wave number and intensity values after 8 hours of exposure, with Folpet being detected in dried spots on the challenge side. GC-ECD-based permeation and IR reflectance data indicated high chemical resistance of the Sol-Vex gloves to an aqueous emulsion of Folpet. [Description provided by NIOSH]
• Subjects:
  Fungi Fungicide, Industrial Occupational Health Personal Protective Equipment Protective Clothing Safety
• Keywords:
  Analytical-processes Author Keywords: Folpet Fungicides Glove Gloves Nitrile Permeation Personal-protective-equipment Pesticide Protection Protective-clothing Protective-materials

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• ISSN:
  1047-322X
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  California ; OSHA Region 9
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  18
• Issue:
  9
• NIOSHTIC Number:
  nn:20025552
• Citation:
  Appl Occup Environ Hyg 2003 Sep; 18(9):658-668
• Contact Point Address:
  Shane S. Que Hee, School of Public Health, University of California at Los Angeles, Los Angeles, California
• CAS Registry Number:
  Folpet (CAS RN 133-07-3)
• Federal Fiscal Year:
  2003
• Performing Organization:
  University of California Los Angeles
• Peer Reviewed:
  True
• Start Date:
  20000601
• Source Full Name:
  Applied Occupational and Environmental Hygiene
• End Date:
  20040531
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:60f44b730462a1f2375d6ba54dfbe5ade6b96d1352cdd316cb9cb5b247e4fb084d5b4e3342f3f4010eb4ee2e5e1cb38c2a31a1ce6ee3dcf8ac0a46d09e4997be
• Download URL:
  https://stacks.cdc.gov/view/cdc/196863/cdc_196863_DS1.pdf
• File Type:
  [PDF - 295.08 KB ]