Immunotoxicology: Role of Inflammation in Chemical-Induced Hepatotoxicity

Details

• Personal Author:
  Gallucci RM ; Luster MI ; Matheson JM ; Simeonova PP ; Yucesoy, Berran
• Description:
  The liver, which is the major organ responsible for the metabolism of drugs and chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseases, such as autoimmunity, are responsible for producing mediators which can effect liver damage or repair. This review will summarize the authors' current understanding of how inflammatory processes influence hepatic pathology and repair following exposure to established hepatotoxic chemicals including carbon tetrachloride (CCl4), an industrial chemical, and acetaminophen (APAP), a widely used analgesic. [Description provided by NIOSH]
• Subjects:
  Digestive System Digestive System Diseases Liver Occupational Health Safety
• Keywords:
  Acetaminophen Author Keywords: Immunotoxicology Hepatocytes Hepatotoxicity Hepatotoxins Immunotoxins Liver-damage Liver-disorders
• ISSN:
  0192-0561
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  22
• Issue:
  12
• NIOSHTIC Number:
  nn:20025427
• Citation:
  Int J Immunopharmacol 2000 Dec; 22(12):1143-1147
• Contact Point Address:
  Michael I. Luster, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26505-2888, USA
• Email:
  mluster@cdc.gov
• CAS Registry Number:
  Carbon tetrachloride (CAS RN 56-23-5)
• Federal Fiscal Year:
  2001
• Peer Reviewed:
  True
• Source Full Name:
  International Journal of Immunopharmacology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:d8da26471b205ebc2634dd892fa51a4c1781da3bf7199eb312ecce837c8ae55cb4ba46741ac848f1e054ab0e0bfa4181165e6148a4eb8f7eca8e6f31fdacbf01
• Download URL:
  https://stacks.cdc.gov/view/cdc/196802/cdc_196802_DS1.pdf
• File Type:
  [PDF - 62.31 KB ]