The Potentiating Action of Tetrandrine in Combination with Chloroquine or Qinghaosu Against Chloroquine-Sensitive and Resistant Falciparum Malaria

Details

• Personal Author:
  Castranova, Vincent ; Dyke KV ; Ye Z
• Description:
  Using chloroquine-sensitive (CS) and chloroquine-resistant (CR) strains of Plasmodium falciparum in vitro, interactions between tetrandrine (TT) and either chloroquine (CQ) or qinghaosu (QHS, artemisinin) were assessed using isobolograms. Sums of the fractional inhibitory concentration for the combination of the two drugs are less than one and therefore, we can conclude that in vitro TT and CQ or QHS act synergistically against CS and CR falciparum malaria. Remarkably, using CR malaria, TT can lower the IC50 dose of CQ as much as 40 fold. These drug combinations may impair the advantage that the development of CQ resistance conveys on the parasite. [Description provided by NIOSH]
• Subjects:
  Communicable Disease Control Microbiology Occupational Health Safety Viral Diseases
• Keywords:
  Disease-control Diseases Drug-interaction Drug-receptor Drugs In-vitro-study Microorganisms Viral-diseases Viral-infections
• ISSN:
  0006-291X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  165
• Issue:
  2
• NIOSHTIC Number:
  nn:20025323
• Citation:
  Biochem Biophys Res Comm 1989 Dec; 165(2):758-765
• Contact Point Address:
  Vincent Castranova, Department of Physiology, West Virginia University, Health Sciences Center, Morgantown, WV 26506
• Federal Fiscal Year:
  1990
• Peer Reviewed:
  True
• Source Full Name:
  Biochemical and Biophysical Research Communication
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:60c01e7ea9d393880866e4d54a039f9bb4c93a66af3515d62059a0c93779f6f5dc058891d2e23c588556d9d687435fa4ae41fa7f8a8c05e4f64dbe50a7059373
• Download URL:
  https://stacks.cdc.gov/view/cdc/196756/cdc_196756_DS1.pdf
• File Type:
  [PDF - 433.94 KB ]