Ovulatory Responses of Adult Mice Treated Neonatally with Estradiol or Methoxychlor (Technical Grade)

Details

• Personal Author:
  Eroschenko VP ; Ford LC ; Swartz WJ
• Description:
  Methoxychlor (MXC), a widely used organochlorine pesticide is estrogenic. To determine its effects on ovulation, one-day-old mice were exposed daily for 14 days to either sesame oil or 1.0 ug estradiol-17B (E), or 0.1 mg, 0.5 mg, or 1.0 mg MXC suspended in sesame oil. At two and four months of age, the animals were injected with a superovulatory regimen of 10 I.U. of pregnant mare's serum followed by 10 I.U. of human chorionic gonadotropin. The chemical treatments produced both a time- and dose- dependent changes. Ovulatory responses and ovarian weights were significantly reduced by two months of age in mice neonatally exposed to E, 0.5 mg, or 1.0 mg MXC. By four months of age, all treated animals exhibited a significant reduction in number of oocytes ovulated in response to exogenous gonadotropin. The ovaries in the treated mice also exhibited fewer fresh corpora lutea and an increase in the number of atretic follicles. It is concluded that neo natal methoxychlor exposures alter ovarian responses to exogenous gonadotropins, resulting in decreased ovulations. [Description provided by NIOSH]
• Subjects:
  Hazardous Substances Insecticides Laboratories Occupational Health Pregnancy Risk Assessment Risk Factors Safety Urogenital Diseases Urogenital System
• Keywords:
  Dose-response Exposure-levels Laboratory-animals Pesticides Prenatal-exposure Reproductive-effects Reproductive-hazards Reproductive-system-disorders Risk-factors Toxic-effects
• ISSN:
  0892-6638
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Abstract or Summary ; Proceedings
• Place as Subject:
  Louisiana ; OSHA Region 6
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  8
• Issue:
  5
• NIOSHTIC Number:
  nn:20025093
• Citation:
  FASEB J 1994 Apr; 8(5)(Pt II):A959
• CAS Registry Number:
  Methoxychlor (CAS RN 72-43-5)
• Federal Fiscal Year:
  1994
• Performing Organization:
  Louisiana State University, School of Medicine, Department of Anatomy, New Orleans, Louisiana
• Peer Reviewed:
  False
• Part Number:
  II
• Start Date:
  19790401
• Source Full Name:
  The FASEB Journal. Experimental Biology '94, Anaheim, California, April 24-28, 1994
• End Date:
  19980831
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:3284ce4a9cd2e06cd65388467c974bdcfbb01dcc213158030abddc7dbd05e26ec33b26d9eeb76a7c7b84a3479e5f8d73ac49a538edb42bc272a2ac0edf795113
• Download URL:
  https://stacks.cdc.gov/view/cdc/196591/cdc_196591_DS1.pdf
• File Type:
  [PDF - 641.46 KB ]