Lack of Correlation Between PM10 Measurements and Upper Respiratory Tract Dose

Details

• Personal Author:
  Fisher D ; McCawley M
• Description:
  A size-selective air intake that has a 50% cut point at 10 microm (PM1O) was developed to monitor those ambient air particulate concentrations that might cause lung disease. The underlying assumption in establishing the current U.S. ambient air monitoring system was that PM1O samples would provide equal protection regard- less of the size distribution of the particulate matter. The size fraction, PM1O, is based on the aerodynamic diameter of particles that are capable of penetrating to, but not necessarily depositing in, the thoracic region of the respiratory system. Epidemiologic studies suggest that exposure to particulate air pollution may cause increased mortality and morbidity from respiratory and cardiovascular disease (Pope et aI, 1996). Epidemiological studies seek a dose-response relationship to understand the etiology of disease. These analyses seek to find the relationship between particulate air pollution and mortality. However, questions about the usefulness of the PM1O estimates have emerged. Previous results suggested that there was a questionable relationship between particulate dose and the PM1O measurement. For occupational environments, McCawley (1993) showed that there is a bias in the relationship between exposure (penetration) and dose (deposition) due to the variations in size distribution in occupational environments. The amount of bias associated with the use of the penetration criteria is dependent upon the particle size distribution. Since deposition is a measurement of dose and as such is the quantity of particulate crossing the physical boundaries of the person and entering the tissue, deposition should relate more directly to response than should measurements such as PM1O which only measure penetration. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Air Pollution Air Pollution, Indoor Cardiovascular Diseases Cardiovascular System Environmental Monitoring Lung Lung Diseases Mortality Occupational Health Respiratory System Respiratory Tract Diseases Safety

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• Keywords:
  Air-contamination Air-quality Air-quality-measurement Air-quality-monitoring Air-samples Air-sampling Cardiovascular-disease Cardiovascular-function Lung-disease Lung-disorders Lung-irritants Mortality-data Mortality-rates Respiratory-system-disorders

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• ISBN:
  0080427405
• ISSN:
  0003-4878
• Publisher:
  Pergamon
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  DRDS - Division of Respiratory Disease Studies
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  14-18
• Volume:
  41
• NIOSHTIC Number:
  nn:20025031
• Citation:
  Ann Occup Hyg, Inhaled Particles VIII 1997 Jan; 41(Suppl 1):14-18
• Editor(s):
  Cherry N; Ogden T
• Federal Fiscal Year:
  1997
• Peer Reviewed:
  True
• Source Full Name:
  Annals of Occupational Hygiene, Inhaled Particles VIII
• Supplement:
  1
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:a7707f5c1d3fbbb701ae80626ff2227b663fa740299e9171de0e06699ea5889a460d1ed8a43365e9d8205a7eb040ac0a6f810ce1f6ed90b206860c8bc3ab2160
• Download URL:
  https://stacks.cdc.gov/view/cdc/196545/cdc_196545_DS1.pdf
• File Type:
  [PDF - 330.36 KB ]