Paternal Occupational Lead Exposure and Pregnancy Outcome

Details

• Personal Author:
  Alexander BH ; Checkoway, Harvey ; Faustman EM ; Kaufman JD ; Mueller BA ; Van Netten C ; Vaughan TL
• Description:
  Self-reported reproductive histories of male employees of a lead-zinc smelter were related to pre-conception measures of lead exposure to examine associations between paternal occupational lead exposure and adverse pregnancy outcome. The participants reported 2,021 pregnancies which resulted in 1,684 normal live births, 12 stillbirths, 30 birth defects, 203 spontaneous abortions, and 92 "other" outcomes. Birth defects and stillbirths were combined for the analysis. The risk of a stillbirth or birth defect was elevated for pre-conception employment in a high-lead-exposure compared with a low-lead-exposure job (odds ratio = 2.7, 95% confidence interval = 0.7, 9.6). A similar risk was found for pre-conception blood lead levels of 25-39 microg/dL and >/= 40 microg/dL when compared with blood lead levels of < 25 microg/dL (OR = 2.9, 95% CI = 0.6, 13.3, and OR = 2.5, 95% CI = 0.5, 11.6, respectively). No association was found between pre-conception lead exposure and spontaneous abortion. A relatively low response rate to the questionnaire and potentially erroneous reporting of reproductive outcomes by male workers are limitations of the study. [Description provided by NIOSH]
• Subjects:
  Biomarkers Demography Epidemiology Hematologic Tests Lead Metals Metal Workers Occupational Exposure Occupational Health Pregnancy Safety Sex Characteristics Urogenital Diseases Urogenital System Workplace Zinc Compounds

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• Keywords:
  Blood-analysis Demographic-characteristics Exposure-levels Lead-compounds Occupational-exposure Reproductive-effects Reproductive-system-disorders Sex-factors Smelters Work-environment Workers Zinc-compounds

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• ISSN:
  1077-3525
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 10 ; Washington
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  280-285
• Volume:
  2
• Issue:
  4
• NIOSHTIC Number:
  nn:20024515
• Citation:
  Int J Occup Environ Health 1996 Oct; 2(4):280-285
• Contact Point Address:
  Elaine M. Faustman, PhD, Department of Environmental Health, Box 354695, University of Washington, Seattle, WA 98195, USA
• CAS Registry Number:
  Lead (CAS RN 7439-92-1) ; Zinc (CAS RN 7440-66-6)
• Federal Fiscal Year:
  1997
• NORA Priority Area:
  Other Occupational Concerns
• Performing Organization:
  University of Washington, Seattle, Washington
• Peer Reviewed:
  True
• Start Date:
  19920401
• Source Full Name:
  International Journal of Occupational and Environmental Health
• End Date:
  19941031
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:418b3f8a2768b7cb16dd2c3cee7158837ee6322694f4be18ea048521dc95b8e5d95bdcc6f7f3a259f754c67415c387d800ea9ec5ee555c22903586e1ce9ebc23
• Download URL:
  https://stacks.cdc.gov/view/cdc/196284/cdc_196284_DS1.pdf
• File Type:
  [PDF - 485.58 KB ]