Oxidative Mechanism of Arsenic Toxicity and Carcinogenesis

Details

• Personal Author:
  Liu KJ ; Shi H ; Shi X
• Description:
  Arsenic is a known toxin and carcinogen that is present in industrial settings and in the environment. The mechanisms of disease initiation and progression are not fully understood. In the last a few years, there has been increasing evidence of the correlation between the generation of reactive oxygen species (ROS), DNA damage, tumor promotion, and arsenic exposure. This article summarizes the current literature on the arsenic mediated generation of ROS and reactive nitrogen species (RNS) in various biological systems. This article also discusses the role of ROS and RNS in arsenic-induced DNA damage and activation of oxidative sensitive gene expression. [Description provided by NIOSH]
• Subjects:
  Arsenic Carcinogens Free Radicals Genetics Inorganic Chemicals Neoplasms Occupational Health Safety
• Keywords:
  Arsenic-compounds Author Keywords: Arsenic Carcinogenesis Cell-damage Disease-incidence Disease-transmission Free-radicals Free Radicals Genetic-factors Oxidative-processes Oxidative Stress Signal Transduction Tumors

  More +
• ISSN:
  0300-8177
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  New Mexico ; OSHA Region 3 ; OSHA Region 6 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  67-78
• Volume:
  255
• Issue:
  1
• NIOSHTIC Number:
  nn:20024345
• Citation:
  Mol Cell Biochem 2004 Jan; 255(1-2):67-78
• Contact Point Address:
  College of Pharmacy, University of New Mexico, Albuquerque, NM 87131, USA
• Email:
  jliu@unm.edu
• CAS Registry Number:
  Arsenic (CAS RN 7440-38-2)
• Federal Fiscal Year:
  2004
• Peer Reviewed:
  True
• Source Full Name:
  Molecular and Cellular Biochemistry
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:98ce6c8610f5359981b2bdef87a6a8154e67f809eb79cc94f103e491a32095b99902b2ba20baf70f68061bb82f02febd293444081a03e47e26c62da1986cf158
• Download URL:
  https://stacks.cdc.gov/view/cdc/196194/cdc_196194_DS1.pdf
• File Type:
  [PDF - 97.04 KB ]