Association of Expired Nitric Oxide with Urinary Metal Concentrations in Boilermakers Exposed to Residual Oil Fly Ash

Details

• Personal Author:
  Aeschliman BD ; Christiani, David C. ; Hauser R ; Herrick, Robert F. ; Houk RS ; Kim JY ; Wand MP ; Woodin MA
• Description:
  Exposure to metal-containing particulate matter has been associated with adverse pulmonary responses. Metals in particulate matter are soluble, hence are readily recovered in urine of exposed individuals. This study investigated the association between urinary metal concentrations and the fractional concentration of expired nitric oxide (FENO) in boilermakers (N = 32) exposed to residual oil fly ash (ROFA). Subjects were monitored at a boiler overhaul site located in the New England area, USA. FENO and urine samples were collected pre- and post-workshift for 5 consecutive workdays. Metals investigated included vanadium (V), chromium (Cr), manganese (Mn), nickel (Ni), copper (Cu), and lead (Pb). The median FENO was 7.5 ppb (95% CI: 7.4-8.0), and the median creatinine-adjusted urinary metal concentrations (microg/g creatinine) were: vanadium, 1.37; chromium, 0.48; manganese, 0.30; nickel, 1.52; copper, 3.70; and lead, 2.32. Linear mixed-effects models indicated significant inverse exposure-response relationships between log FENO and the log-transformed urinary concentrations of vanadium, manganese, nickel, copper, and lead at several lag times, after adjusting for smoking status. Urine samples may be utilized as a biomarker of occupational metal exposure. The inverse association between FENO and urinary metal concentrations suggests that exposure to metals in particulate matter may have an adverse effect on respiratory health. [Description provided by NIOSH]
• Subjects:
  Air Pollutants, Occupational Dust Epidemiology Metals Occupational Exposure Occupational Health Particulate Matter Safety Urine
• Keywords:
  Air Contamination Biological Monitoring Boiler Furnaces Exposure Assessment Fly Ash Industrial Exposures Metal Compounds Particulate Dust Particulates Urinalysis
• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; OSHA Region 1
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  458-466
• Volume:
  44
• Issue:
  5
• NIOSHTIC Number:
  nn:20023845
• Citation:
  Am J Ind Med 2003 Nov; 44(5):458-466
• Contact Point Address:
  Harvard School of Public Health, Occupational Health Program, 665 Huntington Avenue, Building I, Room 1402, Boston, MA 02115
• Email:
  dchris@hohp.harvard.edu
• CAS Registry Number:
  Chromium (CAS RN 7440-47-3) ; Copper (CAS RN 7440-50-8) ; Lead (CAS RN 7439-92-1) ; Manganese (CAS RN 7439-96-5) ; Nickel (CAS RN 7440-02-0) ; Nitric oxide (CAS RN 10102-43-9) ; Vanadium (CAS RN 7440-62-2)
• Federal Fiscal Year:
  2004
• Performing Organization:
  Harvard University, Boston, Massachusetts
• Peer Reviewed:
  True
• Start Date:
  19960930
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20000929
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:14e0ff456ad4d35049e7f6d705ae1b0b6b1daa34dfdb49df191aa27eb3b08a5294a776b19cf668a9d0da93d50c9a1a4dfe86e11cb11e0e9ec580c23104a92b86
• Download URL:
  https://stacks.cdc.gov/view/cdc/195964/cdc_195964_DS1.pdf
• File Type:
  [PDF - 145.71 KB ]