Peroxidation of Phosphatidylserine in Mechanisms of Apoptotic Signaling

Details

• Personal Author:
  Fabisiak JP ; Kagan VE ; Shvedova AA ; Tyurin VA ; Tyurina YY
• Description:
  Asymmetric distribution of major phospholipid classes across membranes is a fundamental characteristic of all cells whose disturbance is incompatible with physiological functions of membranes and with cell viability. 1,2 Under normal conditions, phosphatidylcholine (PC) and sphingomyelin (SPM) are located primarily in the outer leaflet of plasma membrane, whereas aminophospholipidsphosphatidylethanolamine (PE) and phosphatidylserine (PS)-are found almost entirely in the inner leaflet. 1-3 Transmembrane migration and extemalization of PS by apoptotic cells are considered to be the triggering events for their recognition by cognate "scavenger" receptors of macrophages.4 This is followed by phagocytosis and safe digestion of apoptotic cells, thus preventing development of an inflammatory response. [Description provided by NIOSH]
• Subjects:
  Lipids Occupational Health Safety
• Keywords:
  Oxidation Phagocytes Phagocytic Activity Phospholipids Physiological Factors
• ISBN:
  9780121822552
• ISSN:
  0076-6879
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  159-174
• Volume:
  352
• NIOSHTIC Number:
  nn:20023535
• Citation:
  Methods Enzymol 2002 Jul; 352:159-174
• Email:
  exp3@cdc.gov
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Methods in Enzymology
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:f9d48dbaca52683045c099d99003b7370a3052c7f198a727df1ca1fe611528fb34e7c9bcc8877cc40fc22474376204659733e36a26d34ec36dcb55136ef59e01
• Download URL:
  https://stacks.cdc.gov/view/cdc/195905/cdc_195905_DS1.pdf
• File Type:
  [PDF - 766.51 KB ]