IL-1Beta Gene Polymorphisms Influence Hepatitis B Vaccination

Details

• Personal Author:
  Boland GJ ; de Gruijl FR ; Garssen J ; Kashon M ; Luster MI ; Simeonova PP ; Sleijffers A ; van Hattum J ; van Loveren H ; Yucesoy, Berran
• Description:
  Considerable variability exists in the vaccine response to hepatitis B with 5-10% of healthy young adults demonstrating no or inadequate responses following a standard vaccination schedule. As the interleukin-1beta (IL-1beta) cytokine has been shown to be important in the development of immune responses, we determined whether vaccine efficacy is influenced by genetic polymorphisms associated with IL-1beta expression. Ninety-two healthy individuals who were negative for antibodies to hepatitis B antigen (anti-HBs) were vaccinated against hepatitis B according to a standardized schedule. At selected times, antibody titers and lymphoproliferative capacity to hepatitis B surface antigen (HBsAg) were determined. DNA genotyping for IL-1beta polymorphisms using a polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) technique demonstrated that both the anti-HBs titer and the T-cell lymphoproliferative response to HBsAg are significantly increased in individuals possessing the IL-1beta (+3953) minor allelic variant. [Description provided by NIOSH]
• Subjects:
  Blood Blood-Borne Pathogens Communicable Diseases Hematologic Diseases Occupational Health Safety Viral Diseases
• Keywords:
  Author Keywords: IL-1B Gene Bloodborne Pathogens Hepatitis B Vaccination Infection Control Infectious Diseases Liver Liver Cancer Polymorphism Viral Diseases Viral Infections
• ISSN:
  0264-410X
• Document Type:
  Text
• Genre:
  Journal Article
• Place as Subject:
  OSHA Region 3 ; West Virginia
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  HELD - Health Effects Laboratory Division
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Volume:
  20
• Issue:
  25
• NIOSHTIC Number:
  nn:20023346
• Citation:
  Vaccine 2002 Aug; 20(25-26):3193-3196
• Contact Point Address:
  National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, WV 26508
• Federal Fiscal Year:
  2002
• Peer Reviewed:
  True
• Source Full Name:
  Vaccine
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:b772d6afe128101ea519ce34538951c2c9895dedb5caefd6be1aa657c3f52d8828b6f42d1b8a943aa7779089047ea31d3bdb7681962013774b84f40bab1a1f4b
• Download URL:
  https://stacks.cdc.gov/view/cdc/195841/cdc_195841_DS1.pdf
• File Type:
  [PDF - 99.68 KB ]